中心性肥胖2型糖尿病189例血清微RNA-221表达与微血管并发症的关系  

Relationship between serum miR-221 expression and microvascular complications in 189 cases of central obesity T2DM

作　　者：李文静[1] LI Wenjing(Liaocheng Second People's Hospital,Department of Endocrinology,Liaocheng Second HospitalAffiliated to Shandong First Medical University,Liaocheng,Shandong 252600,China)

机构地区：[1]聊城市第二人民医院、山东第一医科大学附属聊城二院内分泌科,山东聊城252600

出　　处：《安徽医药》2024年第1期124-128,共5页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨中心性肥胖2型糖尿病(T2DM)病人血清微RNA-221(miR-221)表达与微血管并发症的关系。方法将2019年6月至2021年9月聊城市第二人民医院收治的中心性肥胖T2DM病人189例作为观察组,另选取181例健康体检者作为对照组,检测并比较两组的血清miR-221表达水平。根据观察组有无并发微血管并发症将其分为并发组和未并发组,采用多因素logistic回归分析微血管并发症发生的影响因素,并绘制受试者操作特征(ROC)曲线分析相关血清指标对微血管并发症发生的诊断价值。结果观察组腹围、身体质量指数和空腹血糖、糖化血红蛋白(HbA1c)、超敏C反应蛋白(hs-CRP)、血尿酸(UA)均高于对照组(P<0.05),血清miR-221水平高于对照组(0.86±0.27比0.32±0.06,P<0.05);观察组微血管并发症发生率为51.32%(97/189);并发组年龄、合并高血压及高脂血症占比、病程、未按时服药占比及空腹血糖、HbA1c、hs-CRP、UA均高于未并发组(P<0.05),血清miR-221水平高于未并发组(0.91±0.25比0.81±0.16,P<0.05),且均是中心性肥胖T2DM病人出现微血管并发症的危险因素(P<0.05);血清miR-221水平诊断中心性肥胖T2DM病人微血管并发症的临界值、灵敏度、特异度、曲线下面积分别为0.83、88.66%、79.35%、0.81,其诊断价值低于HbA1c水平(P<0.05),高于hs-CRP和UA水平(P<0.05),与空腹血糖水平比较差异无统计学意义(P>0.05)。结论血清miR-221水平在中心性肥胖T2DM病人中呈高表达,是微血管并发症发生的危险因素,且对微血管并发症发生具有重要的临床诊断价值。Objective To investigate the relationship between the expression of serum microRNA-221(miR-221)and microvascular complications in patients with central obesity type 2 diabetes mellitus(T2DM).Methods One hundred and eighty-nine patients with central obesity T2DM treated in Liaocheng Second People's Hospital from June 2019 to September 2021 were selected as the observa⁃tion group and 181 healthy people were selected as the control group,and the expression levels of serum miR-221 were detected and compared between the two groups.According to the occurrence of microvascular complications in central obesity T2DM patients,they were assigned into concurrent group and non concurrent group.The influencing factors of microvascular complications were analyzed by multivariate logistic regression,and the receiver operating characteristic curve(ROC)was drawn to analyze the diagnostic value of rele⁃vant serum indicators for microvascular complications.Results The abdominal circumference,body mass index,fasting blood glucose,glycosylated hemoglobin(HbA1c),high-sensitivity C-reactive protein(hs-CRP),uric acid(UA)and serum miR-221 expression(0.86±0.27 vs.0.32±0.06)levels in the observation group were higher than those in the control group(P<0.05).The incidence of microvascular complications in the observation group was 51.32%(97/189).The age,the proportions of hypertension and hyperlipidemia,the course of disease,the proportion of not taking drugs on time,the levels of fasting blood glucose,HbA1c,hs-CRP,UA and the serum miR-221(0.91±0.25 vs.0.81±0.16)in the concurrent group were higher than those in the non concurrent group(P<0.05),and they were the risk factors of microvascular complications in patients with central obesity T2DM(P<0.05).The cut-off value,sensitivity,specificity and area under curve of serum miR-221 level in diagnosis the occurrence of microvascular complications in central obesity T2DM patients were 0.83,88.66%,79.35%and 0.81,respectively.Its diagnostic value was lower than HbA1c level(P<0.05),while highe

关 键 词：糖尿病血管病变 肥胖症 糖尿病 2型 微核糖核酸-221 肥胖 腹部 身体质量指数 

分 类 号：R587.2[医药卫生—内分泌]