嵌合抗原受体T细胞免疫治疗所致细胞因子释放综合征相关细胞因子的研究进展  

Research Progress in Cytokine Release Syndrome-Related Cytokines Caused by CAR-T Cell Therapy

作　　者：郭书芳 汪清铭[2] GUO Shu-fang;WANG Qing-ming(Department of Medicine of Graduate School,the Second Affiliated Hospital of Nanchang University,Nanchang 330006,China;Department of Hematology,the Second Affiliated Hospital of Nanchang University,Nanchang 330006,China)

机构地区：[1]南昌大学研究生院医学部,南昌330006 [2]南昌大学第二附属医院血液内科,南昌330006

出　　处：《南昌大学学报（医学版）》2023年第6期85-89,共5页Journal of Nanchang University：Medical Sciences

基　　金：江西省科技合作专项项目(20212BDH80014)。

摘　　要：嵌合抗原受体T细胞免疫治疗(CAR-T)可导致细胞因子释放综合征(CRS),且多种细胞因子在CRS发生发展中起着重要作用。其中IFN-γ、IL-6是CRS发生的重要驱动因子,IFN-γ、sVCAM-1和Ang-2/Ang-1升高对CRS的发生有预测价值,IFN-γ、IL-6、CRP、GM-CSF、MCP-1等与CRS严重程度相关。阻断IFN-γ、GM-CSF可能可减少CRS的发生。文章明确CAR-T所致CRS相关细胞因子在CRS发生、发展中的角色定位,以期为诊断评估、动态监测、及时处理CRS提供依据。Chimeric antigen receptor(CAR) immunotherapy can result in cytokine release syndrome(CRS),and a variety of cytokines play an important role in the occurrence and development of CRS.Interferon-γ(IFN-γ) and interleukin-6(IL-6)are important drivers for the occurrence of CRS.The increase in IFN-γ,soluble vascular cell adhesion molecule-1 and angiotensin-Ⅱ/angiotensin-I may predict the occurrence of CRS,and the concentrations of IFN-γ,IL-6,C-reactive protein,granulocyte-macrophage colony-stimulating factor(GM-CSF),monocyte chemoattractant protein-1,etc.are related to the severity of CRS.Blocking IFN-γ and GM-CSF may reduce the occurrence of CRS.This article clarifies the role of cytokines related to CAR-T cell therapy caused CRS in the occurrence and development of CRS,and provides a basis for diagnostic evaluation,dynamic monitoring and timely treatment of CRS.

关 键 词：嵌合抗原受体T细胞 免疫治疗 细胞因子释放综合征 细胞因子 

分 类 号：R552[医药卫生—血液循环系统疾病]