贵州14486例儿童血清25-羟基维生素D水平分析  

Analysis of serum 25-hydroxyvitamin D levels in 14486 children in Guizhou

作　　者：任家谋[1] 张春梅 刘娜[3] 冯胜 井沆[4] REN Jia-mou;ZHANG Chun-mei;LIU Na;FENG Sheng;JING Hang(Department of Laboratory Medicine,Guiyang Forth People's Hospital;Department of Obstetrics,Guiyang Second People's Hospital;Department of Geriatrics,Guiyang Forth People's Hospital;Department of Laboratory Medicine,Guizhou Province People's Hospital,Guiyang,Guizhou 550000)

机构地区：[1]贵阳市第四人民医院检验科 [2]贵阳市第二人民医院产科 [3]贵阳市第四人民医院老干科 [4]贵州省人民医院检验科,贵州贵阳550000

出　　处：《赣南医学院学报》2023年第11期1102-1106,1141,共6页JOURNAL OF GANNAN MEDICAL UNIVERSITY

基　　金：贵州省卫生健康委员会科学技术基金项目(GZWKJ2023-452);贵州省人民医院青年基金项目(GZSYQN201708)。

摘　　要：目的:了解贵州0~18岁儿童25-羟基维生素D[25-(OH)D]水平和维生素D营养状况,为科学防治维生素D缺乏提供依据。方法:选取2019年在贵州省人民医院进行常规体检的0~18岁健康儿童,所选儿童肝肾功能均正常,采用化学发光微粒子免疫法检测血清25-(OH)D水平,分别比较不同性别、年龄和季节等分组的25-(OH)D水平和维生素D营养状况。结果:14486例儿童血清25-(OH)D平均浓度为(22.80±9.94)μg·L^(-1),79.21%的儿童25-(OH)D低于理想水平;不同性别组儿童25-(OH)D水平差异无统计学意义(P>0.05),维生素D营养状况在不同性别间差异有统计学意义(P<0.001),女童维生素D缺乏、严重缺乏患病率高于男童(P<0.001);不同年龄组儿童25-(OH)D水平及维生素D营养状况比较差异有统计学意义(P<0.001),随着年龄增长血清25-(OH)D浓度逐渐下降,3岁以上儿童25-(OH)D水平偏低,维生素D缺乏率增高;不同季节组儿童25-(OH)D水平及维生素D营养状况比较差异有统计学意义(P<0.001),夏秋季儿童25-(OH)D水平较高,维生素D缺乏和严重缺乏患病率较低。其他不同特征儿童血清25-(OH)D水平比较:农村人口、孕母高中以下、纯母乳喂养和不规律服用维生素D制剂的儿童血清25-(OH)D水平较低(P<0.05)。结论:贵州0~18岁儿童25-(OH)D水平严重低于理想水平,维生素D明显缺乏,且年龄越大,维生素D缺乏越严重,维生素D水平与年龄、性别、季节、户籍、孕母学历、喂养方式和是否规律服用维生素D制剂相关,与孕母年龄和居住地区无关。应重点关注3岁以上儿童及春冬季节维生素D的补充。Objective:To understand the levels of 25-hydroxyvitamin D[(25-(OH)D)]and the nutritional status of vitamin D in children aged 0-18 years old in Guizhou,and to provide the basis for the scientific prevention and treatment of vitamin D deficiency.Methods:Healthy children aged 0-18 who received routine physical examination at Guizhou Provincial People's Hospital in 2019 were selected.Chemiluminescence microparticle immunoassay was used to detect serum 25-(OH)D levels,and the differences in 25-(OH)D level and vitamin D nutritional status were compared among different genders,ages and seasons.Results:The mean serum 25-(OH)D concentration of 14486 children was(22.80±9.94)μg·L^(-1),and 79.22%of the children's 25-(OH)D was lower than the ideal level.There was no significant difference in 25-(OH)D levels in different gender groups(P>0.05),but the nutritional status of vitamin D was significantly different between different genders,the prevalence of vitamin D deficiency in girls was significantly higher than that in boys(P<0.001);There was a statistically significant difference in 25-(OH)D levels and vitamin D nutritional status among different age groups(P<0.001).The serum 25-(OH)D concentration decreased gradually with the increase of age,the level of 25-(OH)D was significantly lower in children over 3 years old,while the rate of vitamin D deficiency was significantly increased;25-(OH)D levels and vitamin D nutritional status were significantly different in different seasons(P<0.001),25-(OH)D level was higher in summer and autumn,and the prevalence of vitamin D deficiency and deficiency was lower.Children had lower levels of 25-(OH)D and higher prevalence of vitamin D deficiency in spring and winter.Results from other characteristic groups showed that low serum 25-(OH)D levels in children from rural population,the maternal education below high school,children who were exclusively breastfed,and children who took vitamin D preparations irregularly were associated with an increased risk of vitamin D deficiency(P<0.05).Co

关 键 词：儿童 25-羟基维生素D 营养状况 佝偻病 

分 类 号：R729[医药卫生—儿科]