LMR与老年原发性高血压患者焦虑的关系研究  

Relationship between LMR and anxiety in elderly patients with essential hypertension

作　　者：陈余文 王悦 李冰清 李册兴 李文倩 万少枝 孙培媛 吕建峰 CHEN Yuwen;WANG Yue;LI Binqing;LI Cexing;LI Wenqian;WAN Shaozhi;SUN Peiyuan;LYU Jianfeng(Department of Cardiovascular Medicine,Affiliated Renhe Hospital of Three Gorges University,Yichang,Hubei 443000,China)

机构地区：[1]三峡大学附属仁和医院心血管内科,湖北宜昌443000

出　　处：《检验医学与临床》2024年第1期20-23,共4页Laboratory Medicine and Clinic

基　　金：湖北省卫生健康委员会课题(WJ2021F061)。

摘　　要：目的 探究淋巴细胞计数与单核细胞计数比值(LMR)与老年原发性高血压(EH)患者焦虑之间的关系。方法 收集2020年7月至2021年12月在该院心血管内科住院治疗的年龄≥60岁197例EH患者入院时的基本资料、实验室检查指标。以汉密尔顿焦虑量表(HAMA)评分≥14分为临界值,将患者分为焦虑组与无焦虑组,比较两组患者基本资料与入院时LMR等指标差异。采用二元Logistic回归分析老年EH患者发生焦虑的影响因素。采用受试者工作特征(ROC)曲线分析LMR对老年EH患者发生焦虑的预测价值。结果 两组患者在饮酒史、吸烟史、LMR方面比较,差异有统计学意义(P<0.05)。二元Logistic回归分析结果显示,LMR(OR=1.742,95%CI:1.414~2.146,P<0.01)是原发性老年高血压患者发生焦虑的独立危险因素。ROC曲线分析结果显示,LMR预测老年EH患者发生焦虑的曲线下面积(AUC)为0.803(95%CI:0.740~0.866,P<0.001),最佳截断值为4.52,此时的灵敏度和特异度分别是0.71、0.84。结论 LMR水平升高是老年EH患者发生焦虑的独立危险因素,LMR对于老年EH患者发生焦虑具有较好的预测价值。Objective To explore the relationship between the lymphocyte count/monocyte count ratio(LMR)and anxiety in elderly patients with essential hypertension(EH).Methods The basic data and laboratory detection indicators of 197 patients with EH aged≥60 years old hospitalized in the department of cardiovascular medicine in this hospital from July 2020 to December 2021 were collected.With the Hamilton Anxiety Scale(HAMA)score≥14 points as the critical value,the patients were divided into the anxiety group and non-anxiety group,and the differences in the basic data,LMR and other indicators at admission were compared between the two groups.The binary Logistic regression analysis was used to explore the influencing factors of anxiety state occurrence in the elderly patients with EH.The receiver operating characteristic(ROC)curve was adopted to analyze the predictive value of LMR for the anxiety occurrence in the elderly patients with EH.Results There were statistical differences in the drinking history,smoking history and LMR between the two groups(P<0.05).The binary Logistic regression analysis results showed that LMR(OR=1.742,95%CI:1.414-2.146,P<0.01)was an independent risk factor for the anxiety occurrence in the elderly patients with EH.The ROC curve analysis results showed that the area under the curve(AUC)of LMR for predicting the anxiety occurrence in elderly EH patients was 0.803(95%CI:0.740-0.866,P<0.001),and the optimal cut-off value was 4.52,at this point,the sensitivity and specificity were 0.71 and 0.84,respectively.Conclusion Elevated level of LMR is an independent risk factor for the anxiety occurrence in the elderly EH patients and LMR has good predictive value for the anxiety occurrence in the elderly patients with EH.

关 键 词：原发性高血压 焦虑 淋巴细胞计数与单核细胞计数比值 危险因素 

分 类 号：R544.1[医药卫生—心血管疾病]