中西医结合治疗对肺间质纤维化患者的肺功能及纤维化改善作用分析  

Analysis of the Improvement Effect of Combined Traditional Chinese and Western Medicine Treatment on Lung Function and Fibrosis in Patients with Pulmonary Interstitial Fibrosis

作　　者：庞彩苓[1] 王培 王萍[1] 郭英 张英 PANG Cailing;WANG Pei;WANG Ping;GUO Ying;ZHANG Ying(Department of Pulmonary Disease,East Branch,Weifang Hospital of Traditional Chinese Medicine,Weifang,Shandong Province,261000 China)

机构地区：[1]潍坊市中医院东院区肺病科,山东潍坊261000

出　　处：《世界复合医学》2023年第9期17-20,共4页World Journal of Complex Medicine

基　　金：潍坊市软科学研究计划项目(2019RKX051)。

摘　　要：目的分析中西医结合治疗对肺间质纤维化患者的肺功能及纤维化改善作用。方法选取2021年8月—2023年6月于潍坊市中医院接受治疗的92例肺间质纤维化患者为研究对象,采取随机数表法分为甲组和乙组,每组46例,甲组使用常规西药治疗(醋酸泼尼松片、布地奈德混悬液),乙组使用中西医结合治疗(醋酸泼尼松片、布地奈德混悬液与血府逐瘀汤),对比两组血清炎症因子水平、治疗有效率、不良反应发生率以及肺功能指标。结果乙组血清炎症因子IL-1β(8.36±2.01)ng/L低于甲组,差异有统计学意义(t=12.328,P<0.001);乙组不良反应发生率低于甲组,差异有统计学意义(P<0.05);乙组临床治疗总有效率高于甲组,差异有统计学意义(P<0.05);乙组FVC值高于甲组,差异有统计学意义(P<0.05)。结论中西医结合治疗肺间质纤维化患者可获得良好效果,不仅能够有效降低患者的血清炎症因子水平以及不良反应发生率,并且能够进一步改善患者的肺功能指标,整体治疗效果较佳,可使纤维化症状获得一定改善。Objective To analyze the improvement effect of combined traditional Chinese and Western medicine treatment on lung function and fibrosis in patients with pulmonary interstitial fibrosis.Methods 92 patients with pulmonary interstitial fibrosis who were treated in Weifang Hospital of Traditional Chinese Medicine from August 2021 to June 2023 were selected as the study subjects were divided into group A and group B by random number method,with 46 cases in each group.Group A was treated with conventional Western medicine(prednisone acetate,budesonide suspension),and group B was treated with a combination of traditional Chinese and Western medicine(prednisone acetate,budesonide suspension,and Xuefu Zhuyu Decoction).The levels of serum inflammatory factor,treatment effectiveness,incidence of adverse reactions,and lung function indicators were compared between the two groups.Results The serum inflammatory factor IL-1β(8.36±2.01)ng/L in group B was lower than that in group A,and the difference was statistically significant(t=12.328,P<0.001).The incidence rate of adverse reactions in Group B was lower than that in Group A,and the difference was statistically significant(P<0.05).The total clinical treatment effectiveness rate of Group B was higher than that of Group A,the difference was statistically significant(P<0.05).The FVC value of group B was higher than that of group A,and the difference was statistically significant(P<0.05).Conclusion The combination of Chinese and Western medicine can achieve good results in the treatment of patients with pulmonary interstitial fibrosis,and can not only effectively reduce the levels of serum inflammatory factors and the incidence of adverse reactions in patients,and it can further improve the patient's lung function indicators,the overall treatment effect is better,and it can achieve a certain improvement in fibrosis symptoms.

关 键 词：中西药结合 肺间质纤维化 肺功能 不良反应 疗效 

分 类 号：R563[医药卫生—呼吸系统]