呼吸道感染肠道病毒D68型病例特征分析  

Characteristics of cases with enterovirus-D68 infections in the respiratory tract

作　　者：蒋卓婧 黄泽民 王吉玲[2] 陈金堃 JIANG Zhuojing;HUANG Zemin;WANG Jiling;CHEN Jinkun(Department of Microbiological Inspection,Shaoxing Center for Disease Control and Prevention,Shaoxing,Zhejiang 312071,China;Shaoxing Center for Disease Control and Prevention,Shaoxing,Zhejiang 312071,China)

机构地区：[1]绍兴市疾病预防控制中心微生物检验科,浙江绍兴312000 [2]绍兴市疾病预防控制中心,浙江绍兴312000

出　　处：《预防医学》2024年第1期44-46,共3页CHINA PREVENTIVE MEDICINE JOURNAL

基　　金：绍兴市级医卫类科技计划项目(2020A13056)。

摘　　要：目的了解浙江省绍兴市10例呼吸道感染肠道病毒D68(EV-D68)型病例特征,为制定EV-D68感染防制策略提供依据。方法收集2021—2022年绍兴市哨点医院就诊的急性呼吸道感染病例的基本情况和临床标本,采用实时荧光PCR和肠道病毒VP1区测序法检测EV-D68,描述性分析EV-D68阳性病例的流行病学和病原学特征。结果2021—2022年共检测急性呼吸道感染病例3009例,检出EV-D68阳性10例,阳性率为0.33%。其中,男性6例,女性4例;<18岁5例,18~60岁2例,>60岁3例;夏秋季高发,5—7月和9—10月各检出5例。临床症状以发热(10例)、咽痛(9例)和咳嗽(8例)为主;10例病例均恢复良好,无死亡报告。10份EV-D68阳性标本经序列比对均属于D3亚型。结论绍兴市EV-D68引起的呼吸道感染主要感染18岁以下儿童青少年,夏秋季高发,D3亚型为主要流行型别。Objective To investigate the clinical and molecular epidemiological characteristics of 10 patients with enterovirus(EV)-D68 infections in the respiratory tract in Shaoxing City,Zhejiang Province,so as to provide insights into formulation of control interventions for EV-D68 infections.Methods Clinical specimens were sampled from patients with acute respiratory tract infections(ARTIs)admitted to sentinel hospitals in Shaoxing City from 2021 to 2022,and EV-D68 was detected using real-time fluorescent PCR assay and sequencing of the VP1 region of enterovirus.The epidemiological and etiological characteristics of EV-D68 infected cases were descriptively analyzed.Results A total of 3009 specimens were sampled from patients with ARTIs from 2021 to 2022,and the detection of EV-D68 was 0.33%.Of all EV-D68-infected patients,there were 6 men and 4 women,and 5 cases under 18 years of age,2 cases at ages of 18 to 60 years and 3 cases at ages of over 60 years.EV-D68 infection predominantly occurred in summer(5 cases detected between May and July)and autumn(5 cases detected between September and October).The main clinical symptoms included fever(10 cases),sore throat(9 cases)and cough(8 cases),and all 10 cases recovered well,with no deaths reported.Sequencing identified D3 subtype in all 10 specimens positive for EV-D68.Conclusions The ARTIs caused by EV-D68 occurred predominantly among children under 18 years of age in Shaoxing City,and was highly prevalent in summer and autumn.D3 was the predominant enterovirus su7btype.

关 键 词：肠道病毒D68型 呼吸道感染 基因型 病原学监测 

分 类 号：R373.2[医药卫生—病原生物学] R56[医药卫生—基础医学]