单核苷酸多态性(SNP)分析在细菌分子分型中的应用  

Application of single nucleotide polymorphism (SNP) analysisin bacterial molecular typing

作　　者：杨富萍 杨向东[2] 于彬彬[2] 高子厚 YANG Fu-ping;YANG Xiang-dong;YU Bin-bin;GAO Zi-hou(Dali University,Dali 671000,China;Yunnan Provincial Institute for Endemic Disease Control and Prevention,Yunnan Key Laboratory of Natural Focal Disease Prevention and Control Technology,Dali 671000,China)

机构地区：[1]大理大学,大理671000 [2]云南省地方病防治所,云南省自然疫源性疾病防控技术重点实验室,大理671000

出　　处：《中国人兽共患病学报》2023年第12期1196-1201,1210,共7页Chinese Journal of Zoonoses

基　　金：国家自然科学基金(No.81660554,No.30960331);兴滇英才支持计划(No.YNWR-MY-2018-035)~~。

摘　　要：单核苷酸多态性(single nucleotide polymorphism, SNP)作为第三代分子遗传标记,因其在遗传疾病、基因进化、适应和物种、医学等领域的研究重要性而受到广泛的关注。其特征是位点数量多、分布广泛、遗传稳定、通量高,适用于快速、规模化筛查,目前已广泛应用于多种细菌分子分型。本文就SNP技术的概况、与其他分型方法的比较及其在细菌分子分型中的应用进行综述。Single nucleotide polymorphisms(SNPs),third generation molecular genetic markers,have attracted extensive attention because of their importance in research on genetic diseases,gene evolution,adaptation,species,medicine and other fields.SNPs are found in large numbers,with a wide distribution,stable genetics and high throughput.Moreover,SNPs are suitable for rapid and large-scale screening.These genetic markers have been widely used in molecular typing for a variety of bacteria.Herein,the current status of SNP technology is discussed and compared with other typing methods,and its applications in bacterial molecular typing are reviewed.

关 键 词：SNP 细菌 分子分型 

分 类 号：R378[医药卫生—病原生物学]