新生儿红斑狼疮各系统表现及预后研究进展  

Research progress on the manifestations and prognosis of neonatal lupus erythematosus in various systems

作　　者：邵树铭 张懿敏(综述) 张晓蕊(审校)[1] SHAO Shu-Ming;ZHANG Yi-Min;ZHANG Xiao-Rui(Department of Pediatrics,Peking University People's Hospital,Beijing 100044,China)

机构地区：[1]北京大学人民医院儿科,北京100044

出　　处：《中国当代儿科杂志》2024年第1期81-85,共5页Chinese Journal of Contemporary Pediatrics

基　　金：北京市卫生健康委员会北京市临床重点专科项目(2018)-儿科(2199000726)。

摘　　要：新生儿红斑狼疮(neonatal lupus erythematosus,NLE)是由母体的抗-Ro/SSA抗体、抗-La/SSB抗体等自身抗体通过胎盘传给胎儿所致,通常随着患儿体内自身抗体的消失,皮肤黏膜、血液及消化系统等的异常改变可自行消退,但由于自身抗体所导致的各系统损害可能长期存留。该文综述了NLE在皮肤黏膜、血液系统、循环系统、神经系统、消化系统、呼吸系统等方面的表现及预后的研究进展,以期为临床工作提供参考。Neonatal lupus erythematosus(NLE)is caused by the transmission of maternal anti-Ro/SSA antibodies,anti-La/SSB antibodies,and other autoantibodies to the fetus through the placenta.Usually,with the disappearance of autoantibodies in the children's body,abnormal changes in the mucocutaneous,blood system,and digestive system can spontaneously subside,but the damage to various systems caused by autoantibodies may persist for a long time.This article provides a comprehensive review of the manifestations and prognosis of NLE in various systems,including mucocutaneous,blood system,circulatory system,nervous system,digestive system,respiratory system,aiming to provide reference for clinical work.

关 键 词：新生儿红斑狼疮 临床表现 预后 

分 类 号：R722.1[医药卫生—儿科]