FDP、PCT、CRP在老年重症肺炎患者严重程度及预后中的检测意义  

Detection and significance of fibrin degradation product,serum procalcitonin and C-reactive protein in severity and prognosis of elderly patients with severe pneumonia

作　　者：傅丽敏[1] 吴晓[1] 徐冬梅[1] FU Li-min;WU Xiao;XU Dong-mei(Clinical Laboratory,Lishui Central Hospital,Zhejiang 323000,China)

机构地区：[1]丽水市中心医院检验科,浙江323000

出　　处：《中国卫生检验杂志》2023年第23期2870-2873,共4页Chinese Journal of Health Laboratory Technology

摘　　要：目的按探讨纤维蛋白降解产物(FDP)、血清降钙素原(PCT)、C-反应蛋白(CRP)在老年重症肺炎患者严重程度及预后中的检测意义。方法选取本院2022年1月一12月接诊的54例重症肺炎患者,根据患者人院28d的预后情况不同,将预后不良组作为研究组,预后良好者作为对照组。测定2组患者FDP、PCT与CRP水平,并用SPSS26.0、GraphpadPrism7.0软件进行比较,绘制ROC受试者工作曲线比较曲线下面积(AUC)、灵敏度和特异度,比较各指标检测对重症肺炎的诊断性能。用logistic比例风险模型回归分析相应指标对重症肺炎患者预后的危险因素。结果研究组FDP与PCT均高于对照组,差异有统计学意义(P<0.05);logistic回归分析显示FDP是重症肺炎患者预后不良的危险因素(OR=1.185,95%CI:1.03~1.365,P<0.05)。以重症肺炎患者是否在住院期间死亡绘制ROC曲线,FDP预测重症肺炎患者预后的曲线下面积、敏感度和特异度最高,分别为0.877(95%CI:0.783~0.971)、95.24%和78.79%,优于其他单项检测。结论FDP、PCT与重症肺炎患者病情严重程度及预后相关,可作为重症肺炎病情评估的指标,对评估预后有较重要的临床价值。Objective This study aims to explore the significance of fibrin degradation product(FDP),serum procalcitonin(PCT)and C-reactive protein(CRP)detection in the severity and prognosis of elderly patients with severe pneumonia.Methods Fifty-four patients with severe pneumonia admitted to our hospital from January to December 2022 were selected.According to the different prognosis of patients on the 28"day after admission,the patients with poor prognosis were taken as the study group and those with good prognosis as the control group.The levels of FDP,PCT and CRP were measured and compared with SPSS 26.O and Graphpad Prism7.0.ROC receiver operating curve was plotted to draw the area under the curve(AUC),detect sensitivity and specificity,and compare the diagnostic performance of each indicator for severe pneumonia.Logistic pro-portional hazard model was used to analyze the risk factors of prognosis of severe pneumonia patients with corresponding indica-tors.Results FDP and PCT in the study group were higher than those in the control group,and the difference was statistically significant(P<0.05).Logistic regression analysis showed that FDP was a risk factor for poor prognosis in patients with severe pneumonia(OR=1.185,95%CI:1.03-1.365,P<0.05).The ROC curve is drawn according to whether the patients with severe pneumonia died during hospitalization,the area under the curve,sensitivity and specificity of FDP in predicting the prog-nosis of patients with severe pneumonia are the highest,which are 0.877(95%Cl:0.783-0.971),95.24%and 78.79%respectively,which are superior to other single tests.Conclusion FDP and PCT are related to the severity and prognosis of patients with severe pneumonia,which can be used as indicators for evaluating the condition of severe pneumonia and have im-portant clinical value for evaluating the prognosis.

关 键 词：纤维蛋白降解产物 血清降钙素原 C-反应蛋白 老年重症肺炎 预后 

分 类 号：R446[医药卫生—诊断学]