支气管哮喘急性发作患者治疗前后血清TXB_(2)、CCR7水平变化及与肺功能的关系  

Relationship of Changes in Serum TXB2 and CCR7 Levels with Pulmonary Function in Patients with Acute Attack of Bronchial Asthma before and after Treatment

作　　者：王博 高麦仓 梁嘉斌 WANG Bo;GAO Maicang;LIANG Jiabin(Department of Intensive Care Unit,the Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine,Xianyang,Shaanxi 712000,China;Department of Intensive Care Unit,Yangzhou Hongquan Hospital,Yangzhou,Jiangsu 225299,China)

机构地区：[1]陕西中医药大学附属医院重症医学科,陕西咸阳712000 [2]扬州洪泉医院重症医学科,江苏扬州225299

出　　处：《临床误诊误治》2023年第9期53-57,共5页Clinical Misdiagnosis & Mistherapy

基　　金：陕西省自然科学基础研究计划项目(2018JM7122)。

摘　　要：目的分析支气管哮喘(BA)急性发作患者治疗前后血清血栓素B_(2)(TXB_(2))、CC趋化因子受体7(CCR7)水平变化及与肺功能的关系。方法选取2019年5月—2022年5月收治的203例急性发作BA。比较BA急性发作患者治疗前后血清TXB_(2)、CCR7水平及肺功能情况。依据治疗后肺功能损伤程度,将其分为中重度损伤组和轻度损伤组。分析影响BA急性发作患者肺功能损伤加重的危险因素,并探究血清TXB_(2)、CCR7与肺功能的相关性。结果治疗后BA急性发作患者血清TXB_(2)、CCR7水平较治疗前下降,用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、最大呼吸流量(PEF)及FEV1/FVC较治疗前有所上升(P<0.05)。多因素Logistic回归分析显示,血清TXB_(2)、CCR7水平过表达是影响BA急性发作患者肺功能损伤加重的独立危险因素(P<0.05)。BA急性发作患者中,肺功能中、重度损伤31例,肺功能轻度损伤172例。中重度损伤组血清TXB_(2)、CCR7水平高于轻度损伤组(P<0.01)。BA急性发作患者血清TXB_(2)、CCR7水平分别与FVC、FEV1、PEF及FEV1/FVC呈负相关(P<0.01)。结论治疗后BA急性发作患者血清TXB_(2)、CCR7水平显著下降,二者是影响患者肺功能损伤加重的危险因素,密切监测血清TXB_(2)、CCR7水平变化可为临床治疗提供指导。Objective To analyze the relationship between changes in serum thromboxane B_(2)(TXB_(2)),CC chemokine receptor 7(CCR7)levels with pulmonary function in patients with acute attack of bronchial asthma(BA)before and after treatment.Methods A total of 203 patients with acute attack of BA admitted from May 2019 to May 2022 were selected.The levels of serum TXB_(2),CCR7 and pulmonary function of patients with acute attack of BA were compared before and after treatment.According to the degree of pulmonary function injury after treatment,the patients were divided into moderate and severe injury group and mild injury group.The risk factors affecting the exacerbation of pulmonary function injury in patients with acute attack of serum BA were analyzed,and the correlation between serum TXB_(2),CCR7 and pulmonary function was explored.Results After treatment,the levels of TXB_(2) and CCR7 in patients with BA acute attack were decreased compared with those before treatment,and the forced vital capacity(FVC),forced expiratory volume in the first second(FEV1),peak expiratory flow(PEF)and FEV1/FVC were increased compared with those before treatment(P<0.05).Multivariate Logistic regression analysis showed that overexpression of serum TXB_(2) and CCR7 levels was an independent risk factor for the exacerbation of pulmonary function injury in BA patients(P<0.05).Among the patients with acute attack of BA,31 cases had moderate or severe impairment of pulmonary function,and 172 cases had mild impairment of pulmonary function.The levels of serum TXB_(2) and CCR7 in moderate and severe injury group were higher than those in mild injury group(P<0.01).The levels of serum TXB_(2) and CCR7 in patients with acute attack of BA were negatively correlated with FVC,FEV1,PEF and FEV1/FVC,respectively(P<0.01).Conclusion After treatment,the levels of serum TXB_(2) and CCR7 decreased significantly in patients with acute BA attack,which are risk factors for the exacerbation of pulmonary function injury in patients.Close monitoring of the changes of s

关 键 词：支气管哮喘 急性发作 血栓素B_(2) CC趋化因子受体7 肺功能 用力肺活量 最大呼吸流量 危险因素 

分 类 号：R562.25[医药卫生—呼吸系统]