代谢组扩展生物学的“旁中心法则”--对理解基因组学-糖组学-代谢组学-表观基因组学互作的意义  

Extending the “Paracentral Dogma” of Biology with the Metabolome:Implications for Understanding Genomic-Glycomic-Metabolic-Epigenomic Synchronization

作　　者：Albert Stuart Reece 

机构地区：[1]Division of Psychiatry,University of Western Australia,Crawley,WA 6009,Australia

出　　处：《Engineering》2023年第7期16-16,I0001,共2页工程（英文）

摘　　要：The central dogma of biology holds that the transcription of DNA into RNA and the translation of RNA into proteins forms the primary axis of biological activity[1].Following major advances in the description of the complex glycan and lipid chains that are added onto these basic building blocks,the glycome and lipidome have recently been added to this doctrine as an exciting new extension named the"paracentral dogma"[2].However,it has been pointed out that biological systems can indude many layers,which are descibed in modern omics technology platforms relat-ing to both cell-intrinsic and cell-extrinsic layers of control,including metabolomic,microbiomic,immunological,epigenomic,epitranscriptomic,proteomic and phosphoproteomic layers[3].

关 键 词：DES holds HAS 

分 类 号：Q75[生物学—分子生物学]