支气管哮喘急性发作期患儿血清ICAM-1、IL-17与IL-8变化及临床意义  

Changes and Clinical Significance of Serum ICAM-1, IL-17, and IL-8 in Children with Acute Exacerbation of Bronchial Asthma

作　　者：彭定玉 赖春连 韦家美 刘倩华 班健 裴河欢 PENG Dingyu;LAI Chunlian;WEI Jiamei;LIU Qianhua;BAN Jian;PEI Hehuan(Department of Pediatrics,Qinzhou Hospital of Traditional Chinese Medicine,Qinzhou,Guangxi Zhuang Autonomous Region 535019,China;Department of Pneumology,Qinzhou Hospital of Traditional Chinese Medicine,Qinzhou,Guangxi Zhuang Autonomous Region 535019,China;Department of Pharmacy,Qinzhou Hospital of Traditional Chinese Medicine,Qinzhou,Guangxi Zhuang Autonomous Region 535019,China)

机构地区：[1]钦州市中医医院儿科,广西壮族自治区钦州535019 [2]钦州市中医医院呼吸科,广西壮族自治区钦州535019 [3]钦州市中医医院药剂科,广西壮族自治区钦州535019

出　　处：《临床误诊误治》2023年第8期89-93,共5页Clinical Misdiagnosis & Mistherapy

基　　金：广西自然科学基金项目(2016GXNSFBA380203)。

摘　　要：目的 分析血清细胞黏附分子-1(ICAM-1)、白细胞介素-17(IL-17)与白细胞介素-8(IL-8)在支气管哮喘急性发作期患儿中的变化及临床意义。方法 选取2019年2月—2022年2月收治的95例支气管哮喘急性发作期患儿作为观察组,另选取同期体检健康儿99例作为对照组。比较2组血清ICAM-1、IL-17与IL-8水平;记录不同病情患儿血清ICAM-1、IL-17与IL-8水平;使用多因素Logistic回归分析探讨患儿哮喘控制的危险因素。结果 观察组血清ICAM-1、IL-17与IL-8水平均高于对照组(P<0.01)。病情程度越重的患儿血清ICAM-1、IL-17与IL-8水平逐渐升高(P<0.05)。多因素Logistic回归分析显示,血清ICAM-1、IL-17、IL-8水平是影响小儿支气管哮喘控制水平的独立危险因素(P<0.05,P<0.01)。结论 支气管哮喘急性发作期患儿血清ICAM-1、IL-17与IL-8水平明显升高,与疾病发生、发展有着重要联系。Objective To analyze the changes and clinical significance of serum cell adhesion molecule-1(ICAM-1),interleukin-17(IL-17)and interleukin-8(IL-8)in children with acute exacerbation of bronchial asthma.Methods In total,95 children with acute exacerbation of bronchial asthma treated from February 2019 to February 2022 were selected as the observation group,and 99 healthy children undergoing physical examination during the same period were selected as the control group.Serum levels of ICAM-1,IL-17 and IL-8 were compared between the two groups,and were recorded in children with different disease conditions.Multivariate Logistic regression analysis was used to investigate the risk factors affecting asthma control in children.Results The levels of ICAM-1,IL-17 and IL-8 in the observation group were higher than those in the control group(P<0.01).The levels of serum ICAM-1,IL-17 and IL-8 in children with more severe disease were also gradually increased(P<0.05).Multivariate Logistic regression analysis showed that serum ICAM-1,IL-17 and IL-8 levels were independent risk factors affecting the control level of bronchial asthma in children(P<0.05,P<0.01).Conclusion The levels of serum ICAM-1,IL-17 and IL-8 in children with acute exacerbation of bronchial asthma are significantly increased,which has an important relationship with the occurrence and development of the disease.

关 键 词：哮喘 儿童 细胞黏附分子-1 白细胞介素-17 白细胞介素-8 哮喘控制 危险因素 病情程度 

分 类 号：R562.25[医药卫生—呼吸系统]