中医药防治糖尿病肾病的作用机制  

Exploring Mechanism of Traditional Chinese Medicine to Prevent Diabetic Nephropathy

作　　者：裴文丽[1] 史晓伟[1] 连琯[1] 张东鹏[1] 谢卓霖 王黎 PEI Wenli;SHI Xiaowei;LIAN Guan;ZHANG Dongpeng;XIE Zhuolin;WANG Li(Gansu Provincial Hospital of TCM,Lanzhou 730000,Gansu,China)

机构地区：[1]甘肃省中医院,甘肃兰州730000

出　　处：《实用中医内科杂志》2023年第12期16-19,共4页Journal of Practical Traditional Chinese Internal Medicine

基　　金：国家中医优势专科建设项目(甘卫中医函[2023]63号)。

摘　　要：糖尿病肾病(DKD)既是糖尿病最常见的微血管并发症,也是终末期肾病(ESRD)的主要病因之一。DKD病理特征为系膜细胞肥大、足细胞凋亡、肾小球基底膜(GMB)增厚、细胞外基质(ECM)积聚、肾小球硬化、肾小管间质纤维化。其病因涉及高血糖、高血压、高脂血症、肾血流动力学异常、血管活性物质代谢等多种因素。虽然对DKD相关机制探讨已取得一些进展,但现有的临床治疗方法仍不能完全有效地阻止DKD向ESRD发展,中医药作为一种稳定有效的手段可为DKD的防治提供新的方向。从分子水平、细胞水平、遗传水平及代谢水平阐述中医药防治DKD的可能作用机制,以期为中医药防治糖尿病及其并发症提供新视角。Diabetic nephropathy(DKD)is both the most common microvascular complications of diabetes and one of the main causes of end-stage nephropathy(ESRD).The pathological characteristics of DKD are ferrous cellular hypertrophy,foot cell apoptosis,glomerular base film(GMB)thickening,extracellular matrix(ECM)accumulation,glomerular hardening and renal tubular fibrosis.The cause of DKD involves high blood sugar,hypertension,hyperlipidemia,renal blood fluidism and many factors such as vascular active material metabolism.Although the discussion of DKD-related mechanisms has achieved some results,the existing clinical treatment methods still cannot fully effectively prevent DKD from developing to ESRD.Traditional Chinese medicine can provide new directions for DKD as a stable and effective means.Therefore,this article elaborated the possible mechanism of TCM in the prevention and treatment of DKD at the molecular level,cellular level,genetic level and metabolic level,in order to provide a new perspective for TCM in the prevention and treatment of diabetes and its complications.

关 键 词：中医药 糖尿病肾病 作用机制 理论探讨 

分 类 号：R259[医药卫生—中西医结合]