蜂毒及其组分调节氧化应激的研究进展  

Research Progress in the Regulation of Oxidative Stress by Bee Venom and Its Components

作　　者：刘小煜 李莉[2] 杜若飞[3] 毛也然 刘志丹[2] LIU Xiaoyu;LI Li;DU Ruofei;MAO Yeran;LIU Zhidan(Shanghai Second Rehabilitation Hospital,Shanghai 200441,China;Baoshan Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai Baoshan District Integrated Traditional Chinese and Western Medicine Hospital,Shanghai 201999,China;Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海市第二康复医院,上海200441 [2]上海中医药大学附属宝山医院上海市宝山区中西医结合医院,上海201999 [3]上海中医药大学,上海201203

出　　处：《中医药学报》2024年第1期102-108,共7页Acta Chinese Medicine and Pharmacology

基　　金：上海市自然科学基金项目(21ZR1447700);上海市卫生健康委员会科研项目(202140234);上海市人才发展资金资助项目(2020086);上海市宝山区医学重点学(专)科及特色品牌/重点专科B类培育专项(BSZK-2023-BP07)。

摘　　要：蜂毒是天然生物毒素,有较强的生物活性,成分复杂,具有较重要的药用价值。其主要成分为蜂毒肽,具有多种药理活性。蜂毒及其组分的多重作用,部分与调节机体氧化应激密切相关,一方面可以通过抑制氧化应激改善辐射诱导的氧化应激损伤、减轻药物所致的肝肾肺功能受损、抑制肿瘤生长、促进神经功能恢复,另一方面也可能在某些情况下诱导氧化应激造成机体损伤。本文综述了蜂毒及其组分对氧化应激的调节作用,以期为其临床应用和进一步深入研究提供参考。Bee venom is a natural biotoxin with strong biological activity.It has complex components and important medicinal value.The keynote component is melittin,which has various pharmacological activities.The multiple effects of bee venom and its components are partly related to the regulation of oxidative stress.On the one hand,by inhibiting oxidative stress,bee venom can improve radiation-induced oxidative stress damage,reduce the damage of liver,kidney and lung function caused by drugs,inhibit tumor growth,and promote the recovery of nerve function.On the other hand,bee venom may also induce oxidative stress and cause damage to the body in certain situations.This paper reviews the regulatory effects of bee venom and its components on oxidative stress in order to provide reference for its clinical application and further research.

关 键 词：蜂毒 蜂毒肽 氧化应激 

分 类 号：R282.740.5[医药卫生—中药学]