桃红四物汤联合射频消融治疗下肢静脉曲张合并血栓性静脉炎临床研究  

Clinical study of Taohong Siwu Decoction combined with radiofrequency ablation in the treatment of lower extremity varicose veins complicated with thrombophlebitis

作　　者：丁志明[1,2] 王刚 徐阳[1,2] DING Zhiming;WANG Gang;XU Yang(Department of Sore and Vascular Surgery,First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;National Clinical Research Center of Traditional Chinese Medicine Acupuncture,Tianjin 300193,China)

机构地区：[1]天津中医药大学第一附属医院疮疡血管外科,天津300193 [2]国家中医针灸临床医学研究中心,天津300193

出　　处：《天津中医药》2024年第1期18-23,共6页Tianjin Journal of Traditional Chinese Medicine

基　　金：天津市自然科学基金项目(18JCYBJC93600)。

摘　　要：[目的]探究桃红四物汤联合射频消融治疗下肢静脉曲张合并血栓性静脉炎患者的临床疗效。[方法]选择2020年1月至2022年1月于医院治疗的下肢静脉曲张合并血栓性静脉炎患者100例,采用随机数字表法分为射频消融组与桃红四物汤联合组各50例,射频消融组给予患者射频消融治疗,桃红四物汤联合组给予患者桃红四物汤联合射频消融治疗,治疗前、后检测两组患者可溶性血管细胞黏附分子-1(sVCAM-1)、肿瘤坏死因子-α(TNF-α)、白介素-1β(IL-1β)、D-二聚体、一氧化氮(NO)、血栓素B2(TXB2)、内皮素-1(ET-1)、血管性血友病因子(vWF)、6-酮-前列腺素F1α(6-Keto-PGF1α)、纤维蛋白原、血细胞比容、血浆黏度水平,给予患者皮肤温度、肿胀程度、皮肤颜色、疼痛程度评价,比较两组临床疗效。[结果]治疗后,桃红四物汤联合组TNF-α、sVCAM-1、IL-1β、D-二聚体、TXB2、6-Keto-PGF1α、ET-1、vWF、纤维蛋白原、血细胞比容、血浆黏度水平及皮肤温度、肿胀程度、皮肤颜色、疼痛程度评分低于射频消融组(P<0.05);桃红四物汤联合组NO水平、总有效率较射频消融组高(P<0.05)。[结论]给予下肢静脉曲张合并血栓性静脉炎患者桃红四物汤联合射频消融治疗,可抑制炎症,减少血管内皮损伤,改善血液流变学及微循环,缓解患者临床症状,提升患者临床疗效。[Objective]To investigate the clinical efficacy of Taohong Siwu Decoction combined with radiofrequency ablation in the treatment of patients with varicose veins combined with thrombophlebitis of the lower limbs.[Methods]The 100 patients with varicose veins combined with thrombophlebitis of lower extremities treated in hospital from January 2020 to January 2022 were selected and divided into 50 cases each in the radiofrequency ablation group and the combination of Taohong Siwu Decoction group by using the random number table method,and the patients in the radiofrequency ablation group were given radiofrequency ablation treatment,and the patients in the combination of Taohong Siwu Decoction group were given Taohong Siwu Decoction combined with radiofrequency ablation treatment.Soluble vascular cell adhesion molecule-1(sVCAM-1),tumor necrosis factorα(TNF-α),interleukin-1β(IL-1β),D-dimer,nitric oxide(NO),thromboxane B2(TXB2),endothelin-1(ET-1),vascular hemophilia factor(vWF),6-keto-prostaglandin F1α(6-Keto-PGF1α),fibrinogen,hematocrit,and plasma viscosity levels,and patients were given skin temperature,swelling degree,skin color,and pain evaluation to compare the clinical efficacy of the two groups.[Results]After treatment,the scores of TNF-α,sVCAM-1,IL-1β,D-dimer,TXB2,6-Keto-PGF1α,ET-1,vWF,fibrinogen,hematocellular volume,plasma viscosity,skin temperature,swelling degree,skin color and pain degree in Taohong Siwu Decoction combined group were lower than those in radiofrequency ablation group(P<0.05).The NO level and total effective rate of Taohong Siwu Decoction combined group were higher than those of radiofrequency ablation group(P<0.05).[Conclusion]Taohong Siwu Decoction combined with radiofrequency ablation for patients with lower extremity varicose veins complicated with thrombophlebitis can inhibit inflammation,reduce vascular endothelial damage,improve hemorheology and microcirculation,alleviate clinical symptoms and improve clinical efficacy.

关 键 词：桃红四物汤 射频消融 下肢静脉曲张合并血栓性静脉炎 血管内皮损伤 

分 类 号：R543.6[医药卫生—心血管疾病]