全球农业动物基因编辑基础研究发展动态分析  

Analysis of the Development Trends in Global Agricultural Animal Gene Editing Fundamental Research

作　　者：张萌萌 蒋颖 李宁 ZHANG Meng-Meng;JIANG Ying;LI Ning(Beijing Capital Agribusiness Future Biotechnology Co.,Ltd.,Beijing100088,China)

机构地区：[1]北京首农未来生物科技有限公司,北京100088

出　　处：《农业生物技术学报》2024年第1期220-233,共14页Journal of Agricultural Biotechnology

摘　　要：基因编辑技术是一项可以对生物机体DNA序列进行精准修饰的技术。为了解全球该领域特别是针对农业动物基因编辑的发展趋势,本研究运用文献计量法,统计2015~2022年基因编辑技术领域论文数据,系统分析了该领域主要研发机构、研发团队、研究前沿热点以及农业动物基因编辑技术研究现状。结果表明,我国基因编辑技术在论文层面处于国际领先地位,2015~2022年统计基因编辑技术相关论文量居全球第2,全球排名前20机构中,中国机构含8个,占40%。但与发达国家(美国)相比,我们还存在差距,主要体现在底盘核心技术创新不足,基因编辑系统开发、优化及Cas蛋白发现等均在国外;国际顶级学术期刊发表论文虽居全球第2,但远不及美国,中国在《自然-生物技术》(Nature Biotechnology)期刊中发文量最多(31篇),仅占美国发文量的五分之一;基因编辑技术在农业动物中的研究报道整体数量较少,但呈逐年增多趋势,其在农业动物育种领域的应用存在巨大的潜力;最后结合自身国情,展望基因编辑技术前景以及在农业动物育种领域的发展趋势,以期为利用基因编辑技术解决农业动物育种特别是抗病育种中重大难题提供参考。Gene editing technology is a precise modification technique that can manipulate DNA sequences in living organisms.In order to understand the global development trends in this field,particularly with regard to agricultural animal gene editing,the present study utilized the bibliometric methods to analyze research data from 2015 to 2022 in the field of gene editing technology.In this study,we systematically examined the main research institutions,teams,research frontiers,and current status of agricultural animal gene editing technology research.The results showed that China is in a leading position internationally in gene editing technology research at the literature level,as it is ranked second in the world in terms of the number of gene editing technology-related papers published between 2015 and 2022.Eight of the top 20 institutions being in China,accounting for 40%of the total in the world.However,compared with developed countries,such as the United States,China still lags behind in terms of core technology innovation,gene editing system development,optimization and Cas protein discoveries,all of which are mainly being conducted overseas.Although China ranks second in the world in terms of the number of papers published in top international academic journals,however,it is far behind the United States.In the Nature Biotechnology,China accounts for only one-fifth of the total number of papers,with 31 papers published.The number of research reports on gene editing technology in agricultural animals is relatively small,but it is increasing year by year.The application of gene editing technology in animal breeding has immense potential in the field of agricultural animal breeding,particularly in developing disease-resistant breeds.Finally,we look forward to the prospect of gene editing technology and the development trends of agricultural animal breeding field based on the current situation and national conditions,in order to provide us with a reference for using gene editing technology to solve major problems in ag

关 键 词：基因编辑 农业动物 文献分析 全球 

分 类 号：S185[农业科学—农业基础科学]