2022年四川省健康人群乙肝病毒表面抗体监测结果  

Monitoring results of hepatitis B surface antibody among healthy population in Sichuan Province in 2022

作　　者：刘亿 刘宇[1] 刘力进 刘家洁[1] 李银乔[1] 杨庆 张恺 LIU Yi;LIU Yu;LIU Lijin;LIU Jiajie;LI Yinqiao;YANG Qing;ZHANG Kai(Sichuan Center for Disease Control and Prevention,Chengdu 610041,Sichuan Province,China)

机构地区：[1]四川省疾病预防控制中心,成都610041

出　　处：《职业卫生与病伤》2023年第6期348-351,共4页Occupational Health and Damage

摘　　要：目的 了解2022年四川省健康人群乙肝病毒表面抗体(hepatitis B surface antibody,HBsAb)阳性情况,评估人群免疫情况,为制定相关免疫策略提供参考依据。方法 2022年将四川省各县(区)按照人均地区生产总值划分为高、中、低经济水平3层,每层随机抽取1~2个县(区)共4个地区,每个监测地区分10个年龄组,每组不少于44人,调查其基本信息,并采集血清,使用化学发光法检测血清中的HBsAb,分析HBsAb阳性率。采用χ^(2)检验进行统计分析,检验水准α=0.05,使用SPSS 24.0软件。结果 共调查1 795人,HBsAb阳性率为68.41%。不同经济发展水平地区HBsAb阳性率在60.21%~76.59%之间,城市、农村健康人群HBsAb阳性率分别为74.94%和61.87%,不同年龄组HBsAb阳性率在36.31%~99.45%之间;不同地区和不同人群HBsAb阳性率均有差异(P均<0.05)。男、女性HBsAb阳性率分别为66.67%和69.95%,无或不详、有乙肝疫苗(hepatitis B vaccine,HepB)免疫史人群HBsAb阳性率分别为63.77%和74.74%,HBsAb阳性率均无差异(P均>0.05)。结论 2022年四川省4个监测县(区)中经济发展水平较低的地区和6~17岁人群为免疫薄弱地区和人群;加大重点地区卫生投入,做好常规接种和查漏补种;加强重点人群健康教育,考虑实施加强免疫;定期开展HBsAb水平监测,及时掌握人群HBsAb水平。Objective To understand the positive status of hepatitis B surface antibody (HBsAb) in healthy population in Sichuan Province in 2022,to evaluate population immunity,and to provide reference for the development of relevant immunization strategies.Methods In 2022,the counties districts in Sichuan Province were divided into three levels of high,medium and low economic level according to the per capita regional gross domestic product (GDP).One or two counties districts were randomly selected from each level,and a total of four counties/districts were enrolled For each monitoring area,the population was divided into ten age groups,with no less than 44people in each group.Subjects were investigated for their basic information and serum samples were collected.Serum HBsAb was detected by chemiluminescence.The positive rate of HBsAb was analyzed.Statistical analysis was performed by Chi-square test,with a significance level of α=0.05SPSS 24.0 software was used.Results A total of 1 795 people were surveyed,and the positive rate of HBsAb was 68.41%.The positive rates of HBsAb in areas with different economic development levels ranged from 60.21%to 76.59%.The positive rates of HBsAb in urban and rural healthy populations were 74.94%and 61.87%,respectively,and the positive rates of HBsAb in different age groups ranged from 36.31%to 99.45%.The positive rates of HBsAb were significantly different in different areas and different ages (all P<0.05).The positive rates of HBsAb in men and women were 66.67%and 69.95%,respectively.The positive rates of HBsAb in people with no/unknown and with a history of hepatitis B vaccine immunization were 63.77%and 74.74%,respectively.There were no significant differences in the positive rate of HBsAb between different immune history groups and different gender groups (all P>0.05).Conclusions In the four monitoring counties/districts,the areas with low economic development level and the population aged 6-17 years were weak at immunization.It is suggested to increase health investment in key are

关 键 词：四川省 乙肝 乙肝表面抗体 

分 类 号：R512.62[医药卫生—内科学]