猪肠道冠状病毒感染机制的研究进展  

Research progress in the mechanism of porcine intestinal coronavirus infection

作　　者：张琦[1] 周娜娜 李佳璇[1,2] 崔文 姜艳平[1,2] 唐丽杰 ZHANG Qi;ZHOU Na-na;LI Jia-xuan;CUI Wen;JIANG Yan-ping;TANG Li-jie(College of Veterinary Medicine,Northeast Agricultural University,Harbin 150030,China;Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development,Harbin 150030,China)

机构地区：[1]东北农业大学动物医学学院,黑龙江哈尔滨150030 [2]黑龙江省动物疾病防控与制剂创制重点实验室,黑龙江哈尔滨150030

出　　处：《中国兽医科学》2023年第12期1579-1584,共6页Chinese Veterinary Science

基　　金：黑龙江省自然科学基金项目(LH2021C042);国家自然科学基金联合基金项目(U22A20527)。

摘　　要：猪肠道冠状病毒(swine enteric coronavirus,SeCoV)是引起猪病毒性腹泻的重要病原,在世界范围内广泛流行,给全球养猪业带来了危害。本文综述了4种主要的猪肠道冠状病毒感染机制的研究,即传染性胃肠炎病毒(TGEV)、猪流行性腹泻病毒(PEDV)、猪德尔塔冠状病毒(PDCoV)和猪急性腹泻综合征冠状病毒(SADS-CoV),包括通过受体APN侵入细胞并诱导宿主细胞凋亡、逃逸宿主的天然免疫,以及与宿主细胞内质网应激系统相互作用的机制,以便为猪肠道冠状病毒研究及相关疾病防控提供参考。Swine enteric coronavirus(SeCoV)is an important pathogen causing viral diarrhea in pigs,which is widely prevalent in the world and brings harm to the global pig industry.This paper reviews the research on the infection mechanism of four major porcine enteric coronaviruses:transmissible gastroenteritis virus(TGEV),porcine epidemic diarrhea virus(PEDV),porcine delta coronavirus(PDCoV)and swine acute diarrhea syndrome coronavirus(SADS-Cov),including the mechanism of invading cells and inducing host cell apoptosis through recipient APN,escaping from the host's natural immunity,and interacting with the host's endoplasmic reticulum stress system,It provides reference for the research of enteric coronavirus and the prevention and control of related diseases.

关 键 词：猪肠道冠状病毒 细胞凋亡 免疫逃逸 内质网应激 感染机制 

分 类 号：S852.659.6[农业科学—基础兽医学]