巨噬细胞与缺血-再灌注损伤相关研究进展  

Research progress on association between macrophages and ischemia-reperfusion injury

作　　者：刘琦 张燕楠 孙启全 Liu Qi;Zhang Yannan;Sun Qiquan(不详;School of Medicine,South China University of Technology,Guangzhou 510641,China)

机构地区：[1]华南理工大学医学院,广州510641 [2]南方医科大学附属广东省人民医院(广东省医学科学研究院)肾移植科

出　　处：《器官移植》2024年第1期40-45,共6页Organ Transplantation

基　　金：国家自然科学基金面上项目(82270783)。

摘　　要：缺血-再灌注损伤(IRI)是一个极其复杂的病理生理过程,可在心肌梗死、卒中、器官移植、涉及暂时中断血流的手术等过程中发生。巨噬细胞作为免疫系统的关键分子,在IRI的发病机制中起着至关重要的作用。M1型巨噬细胞是促炎细胞,参与病原体的清除;而M2型巨噬细胞具有抗炎作用,参与组织修复和重塑以及细胞外基质重塑。巨噬细胞表型之间的平衡对于IRI的结局和治疗十分重要。本文综述了巨噬细胞在IRI中的作用,包括巨噬细胞M1/M2表型平衡、向不同缺血组织浸润和募集的机制。此外,还讨论了IRI过程中靶向巨噬细胞的潜在治疗策略,为减轻IRI和促进组织修复相关研究提供参考。Ischemia-reperfusion injury(IRI)is an extremely complicated pathophysiological process,which may occur during the process of myocardial infarction,stroke,organ transplantation and temporary interruption of blood flow during surgery,etc.As key molecules of immune system,macrophages play a vital role in the pathogenesis of IRI.M1 macrophages are pro-inflammatory cells and participate in the elimination of pathogens.M2 macrophages exert antiinflammatory effect and participate in tissue repair and remodeling and extracellular matrix remodeling.The balance between macrophage phenotypes is of significance for the outcome and treatment of IRI.This article reviewed the role of macrophages in IRI,including the balance between M1/M2 macrophage phenotype,the mechanism of infiltration and recruitment into different ischemic tissues.In addition,the potential therapeutic strategies of targeting macrophages during IRI were also discussed,aiming to provide reference for alleviating IRI and promoting tissue repair.

关 键 词：缺血-再灌注损伤 巨噬细胞 炎症反应 活性氧簇(ROS) 趋化因子 黏附因子 抗炎剂 干细胞治疗 

分 类 号：R617[医药卫生—外科学] R329.2[医药卫生—临床医学]