供肝保存液的演变和革新  

Evolution and innovation of preservation fluid for donor liver

作　　者：喻国涛 尹燕锋[1] 颜春涛 邹光旭 张黄燕 马丽 胡宗强[1] Yu Guotao;Yin Yanfeng;Yan Chuntao;Zou Guangxu;Zhang Huangyan;Ma Li;Hu Zongqiang(Department of Hepatobiliary Pancreatic Surgery,the First People’s Hospital of Kunming,Kunming 650011,China)

机构地区：[1]昆明市第一人民医院肝胆胰外科,昆明650011

出　　处：《器官移植》2024年第1期131-137,共7页Organ Transplantation

基　　金：国家自然科学基金(82060436);云南省科学技术厅中青年学术和技术带头人后备人才项目(202205AC160089);云南省科学技术厅重大科技专项项目(202302AA310018);昆明医科大学研究生创新基金(2023S397)。

摘　　要：器官保存液能够改善移植物冷缺血损伤和维持移植物良好的功能。目前,如何减少供肝在冷缺血期间引起的一系列损伤,改善和提高移植物的保存质量,是目前该领域研究的热点和难点。现阶段,临床上的保存液仍未达到理想的保存效果,尤其是对于边缘供器官的保护作用不尽如人意。在当今供者极度匮乏的情况下,为了改善移植物免受冷缺血损伤,其关键要素仍然是寻求最佳的供肝保存方案。本文总结了供肝在冷缺血期间的损伤机制,保存液的分类及供肝保存液的演变历程,探讨了供肝保存液的发展方向及面临的困境,为供肝保存液的研发提供新思路和参考。Organ preservation fluid could mitigate cold ischemia injury and maintain normal function of the grafts.At present,how to reduce a series of injury caused by cold ischemia of donor liver and improve the preservation quality of grafts are the hot and challenging spots in this field.Currently,preservation fluid in clinical practice has not achieved ideal preservation effect,especially for the protection of marginal donor organs.In the context of severe donor shortage,the key solution is still to explore the optimal preservation protocol for donor liver to prevent grafts from cold ischemia injury.In this article,the mechanism of donor liver injury during cold ischemia,the classification and evolution of donor liver preservation fluid were summarized,the development direction and challenges of donor liver preservation fluid were discussed,aiming to provide novel ideas and references for the research and development of donor liver preservation fluid.

关 键 词：肝移植 供肝 保存液 冷缺血损伤 扩大标准供者 边缘供肝 氧化应激 缺血-再灌注损伤 

分 类 号：R617[医药卫生—外科学] R575[医药卫生—临床医学]