分子动力学模拟在生物化学课程教学中的探索  

Exploration of Molecular Dynamics Simulation in Biochemistry Teaching

作　　者：王树栋 郑璇[2] WANG Shu-dong;ZHENG Xuan(Guizhou Police College,Guiyang,Guizhou,550000,China;Kaili University,Kaili,Guizhou,556011,China)

机构地区：[1]贵州警察学院,贵州贵阳550000 [2]凯里学院,贵州凯里556011

出　　处：《凯里学院学报》2023年第6期90-94,共5页Journal of Kaili University

基　　金：贵州警察学院博士创新人才支持计划项目(KY2024XJPD001)。

摘　　要：借助分子动力学模拟软件NAMD,探索了分子动力学模拟在生物化学教学中的应用,使学生对DNA中碱基对之间的Watson-Crick氢键、碱基与碱基之间的π-π堆积作用有了具体深入的认识,可进一步加深对DNA二级结构特点的认识和理解.结合可视化软件VMD,更加形象地向学生展示DNA的多种形态.通过探索,激发了学生的学习兴趣,提高了生物化学课程的教学质量.With the help of NAMD,the application of molecular dynamics simulation in teaching bio⁃chemistry was explored.Students have a specific and in-depth understanding of the Watson Crick hy⁃drogen bond between base pairs and theπ-πstacking effect between bases in DNA,which further deepened their knowledge and understanding of the secondary structure characteristics of DNA.Com⁃bined with VMD,it more vividly demonstrates the various forms of DNA to students.The exploration has stimulated students'learning interest and improved the quality of biochemistry teaching.

关 键 词：生物化学 分子动力学模拟 DNA二级结构 氢键 Π-Π堆积 

分 类 号：G642[文化科学—高等教育学]