探讨中药及其成分对细菌生物被膜耐药抑制作用的研究进展  

Research progress on the inhibitory effect of Chinese herbs and their components on bacterial biofilm resistance

作　　者：陈雯 丁纯蕾[1] 孙旗 沈梦雯[1] 钱风华[1] 郝微微 CHEN Wen;DING Chunlei;SUN Qi;SHEN Mengwen;QIAN Fenghua;HAO Weiwei(Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China)

机构地区：[1]上海中医药大学附属岳阳中西医结合医院急诊医学科,200437 [2]上海中医药大学附属曙光医院脾胃病科

出　　处：《环球中医药》2024年第1期144-149,共6页Global Traditional Chinese Medicine

基　　金：2020年上海市卫健委/传染病中医药防治能力建设项目(ZYYB-FRMZ-03);上海中医药大学预算内科研项目(2020LK056)。

摘　　要：细菌生物被膜是细菌对抗生素产生耐药的关键作用靶点,主要涉及被膜屏障功能、外排泵表达以及膜内微环境等多个方面作用。传统中医药经历了几千年的发展,具有来源广、成分复杂、不易产生耐药等多方面优势,在治疗耐药菌所致的感染性疾病上见解独到。中药及其成分除了具有一定的抗菌效果以外,还可以通过抑制、破坏被膜,提高被膜通透性,改变外排泵表达等来降低细菌生物被膜的耐药作用。本文主要通过收集整理国内外相关文献,梳理总结细菌生物被膜的主要耐药机制以及中药及其成分对细菌生物被膜耐药抑制作用的相关研究成果,以期为更好的解决细菌耐药性增加这一严峻问题提供新的治疗思路与方法,并为中药在治疗细菌感染性疾病的应用上提供较为充分的理论依据。Bacterial bioepithelium is a key target for bacterial resistance to antibiotics,which mainly involves the barrier function of the periplasm,the expression of efflux pumps and the intramembrane microenvironment.Traditional Chinese medicine,which has thousands of years of development,has the advantages of wide source,complex composition,and not easy to produce drug resistance,and has unique insights in the treatment of infectious diseases caused by drug-resistant bacteria.In addition to their antimicrobial effects,Chinese medicines and their components can also reduce the drug-resistant effects of bacterial biofilms by inhibiting and destroying the periplasm,increasing the permeability of the periplasm,and altering the expression of efflux pumps.This paper summarized the main drug resistance mechanisms of bacterial biofilms and the research results of Chinese medicines and their components on the inhibition of bacterial biofilm resistance by collecting and arranging the relevant literature at home and abroad,with a view to providing new therapeutic ideas and methods for better solving the serious problem of the increase of bacterial drug resistance,as well as to provide a more adequate theoretical basis for the application of Chinese medicines in the treatment of bacterial infectious diseases.

关 键 词：细菌耐药性 生物被膜 耐药机制 中医药 中药成分 

分 类 号：R285[医药卫生—中药学]