3-(二氟甲基)-1-甲基-1H-吡唑-4-羧酸合成概述  

Overview of Synthesis of 3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic Acid

作　　者：成鸿静 钟若楠 胡伟 曾敬 欧阳宇迪 刘源 蒋利 CHENG Hong-jing;ZHONG Ruo-nan;HU Wei;ZENG Jing;OUYANG Yu-di;LIU Yuan;JIANG Li(National Engineering Research Center for Agrochemicals,Hunan Research Institute of Chemical Industry Co.,Ltd.,Changsha 410014,China;Agrochemical Key Laboratory of Hunan Province,Changsha 410014,China;Hunan Haili Changde Pesticide&Chemicals Co.,Ltd.,Changde 415001,China)

机构地区：[1]湖南化工研究院有限公司国家农药创制工程技术研究中心,湖南长沙410014 [2]农用化学品湖南省重点实验室,湖南长沙410014 [3]湖南海利常德农药化工有限公司,湖南常德415001

出　　处：《精细化工中间体》2023年第6期6-9,共4页Fine Chemical Intermediates

基　　金：“芙蓉计划”湖南省企业科技创新创业团队项目(湖南海利化工新材料科技创新创业团队)。

摘　　要：琥珀酸脱氢酶抑制剂(SDHI)类杀菌剂因其持效性和稳抗性显著,3-(二氟甲基)-1-甲基-1H-吡唑-4-羧酸作为该类杀菌剂的中间体在未来几十年具有相当广阔的市场前景。综合国内外文献研究,探讨了3-(二氟甲基)-1-甲基-1H-吡唑-4-羧酸各合成工艺方法,并对比了各种方法的优缺点,对3-(二氟甲基)-1-甲基-1H-吡唑-4-羧酸合成方法的发展进行了展望。Succinate dehydrogenase inhibitor(SDHI)fungicides have significant efficacy and stability resistance,as an intermediate 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid will have a broad market prospect in the next few decades.Based on a comprehensive review of reported literature both domestically and internationally,the synthesis routes of 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid were discussed,and the advantages and disadvantages of various methods were compared.The development of synthesis methods for 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid was prospected while a prospective outlook on the development of synthesis techniques for 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid was also provided.

关 键 词：琥珀酸脱氢酶抑制剂 3-(二氟甲基)-1-甲基-1H-吡唑-4-羧酸 中间体 

分 类 号：S482.2[农业科学—农药学]