国产创新钾离子竞争性酸阻滞剂在酸相关疾病中的应用价值  

Application Value of Domestic Innovative Potassium-competitive Acid Blocker in Acid-related Diseases

作　　者：孟宇 赵梦蕊 赵琨 隋忠国[3] 王进 MENG Yu;ZHAO Meng-rui;ZHAO Kun;SUI Zhong-guo;WANG Jin(Beijing North Medical&Health Economic Research Center,Beijing 100020,China;Vanke School of Public Health,Tsinghua University,Beijing 100084,China;The Affiliated Hospitalof Qingdao University,Shandong Qingdao 266000,China)

机构地区：[1]北京北方医药健康经济研究中心,北京100020 [2]清华大学万科公共卫生与健康学院,北京100084 [3]青岛大学附属医院,山东青岛266000

出　　处：《中国药物评价》2023年第6期498-501,共4页Chinese Journal of Drug Evaluation

基　　金：国家“重大新药创制”科技重大专项资助项目(项目编号:2020ZX09101013,项目名称:新型钾离子竞争性酸阻滞剂(P-CAB)药物LXI-15028的临床研究)。

摘　　要：酸相关疾病是消化科常见疾病,具有病程长、易复发的特点,经常导致烧心、反酸等不适症状,给患者的日常活动、工作效率和生活质量等方面带来不利影响。抑酸是酸相关疾病治疗的关键,从最初的弱碱性药品、H2受体拮抗剂到目前最常用的质子泵抑制剂。近年来,新一代钾离子竞争性酸阻滞剂(Potassium-competitive acid blocker,P-CAB)的出现,实现了更快、更持久、更稳定的抑酸作用。目前全球已有多款P-CAB获批酸相关疾病适应证,替戈拉生作为我国首款自主研发的P-CAB,不仅为我国酸相关疾病治疗带来新选择,也对我国新药研发具有重大意义。本研究基于替戈拉生相关循证医学证据,梳理国产创新P-CAB在酸相关疾病中的价值,为酸相关疾病临床用药提供参考依据。Acid-related diseases(ARDs)are common in the digestive department with characteristics of long course and frequent relapse,causing symptoms of heartburn and acid reflux which can adversely affect the patients′daily activities,work efficiency,and quality of life.Acid suppression is the key to ARDs treatment,including weakly alkaline drugs,H2 receptor antagonist,and the most commonly used proton pump inhibitor.Subsequently,the advent of potassium-competitive acid blocker(P-CAB)achieves a faster,longer-lasting,and stabler acid-suppressing effect.Until the current time,there are already multiple P-CABs for ARDs on the market worldwide.Tegoprazan,China′s first independently developed P-CAB,not only provide a new selection for ARDs patients,but also has a great significance for new drug research and development in China.This article combed the value of domestic innovative P-CAB in acid-related diseases based on the evidence-based medical proof of tegoprazan,providing references for clinical medication in ARDs and benefiting more patients.

关 键 词：酸相关疾病 胃食管反流病 反流性食管炎 钾离子竞争性酸阻滞剂 替戈拉生 

分 类 号：R916.68[医药卫生—药学] R975.2