基于“药邪理论”浅析激素性股骨头坏死病机  

Analyzing the Pathogenesis of Steroid-Induced Necrosis of the Femoral Head Based on the"Medicinal Toxins Theory"

作　　者：周长安 黄琼 ZHOU Chang-an;HUANG Qiong(Medical Science Department,Hubei University for Nationalities,Enshi Hubei,445000,China;Department of Orthopedics,Gaoqing County Hospital of Traditional Chinese Medicine,Zibo Shandong,256399,China)

机构地区：[1]湖北民族大学医学部,湖北恩施445000 [2]淄博市高青县中医医院骨伤科,山东淄博256399

出　　处：《中华养生保健》2024年第2期81-83,87,共4页CHINESE HEALTH CARE

摘　　要：“药邪”为药物炮制或使用不当引起的人体生理生化功能紊乱。“激素性股骨头坏死”指高剂量激素导致股骨头活性成分死亡的病理过程。基于“药邪理论”,结合糖皮质激素对股骨头的不利影响,分析激素性股骨头坏死发生发展的病机;激素作为药邪,影响激素性股骨头坏死的病机归结为气血凝滞,气滞血瘀或津液失调,痰瘀互结,进而内舍脏腑,损肝脾肾,最终导致骨失濡养,久而坏死。治疗以行气、祛瘀、化痰、补肾为基本治法,除邪以安疾。基于此理论,为今后实验验证及临床治疗提供思路。"Medicine evil"is the human physiological and biochemical dysfunction caused by the processing or improper use of drugs.Steroid-induced Necrosis of the Femoral Head"refers to the pathological process in which high doses of hormones lead to the death of the active components of the femoral head.Drawing upon the principles of the"Medicinal Toxins Theory"and acknowledging the detrimental effects of glucocorticoids on the femoral head,this study delves into the pathogenesis of steroid-induced necrosis of the femoral head through the lens of traditional Chinese medicine.Within this framework,hormones are viewed as medicinal toxins that play a significant role in infl uencing the development of steroid-induced necrosis.This infl uence is attributed to factors such as the stagnation of Qi and blood,the amalgamation of fl uid imbalance,phlegm,and stasis,as well as internal organ impairment impacting the liver,spleen,and kidney,ultimately leading to bone malnutrition and necrosis over time.In terms of treatment,the focus lies on fundamental methods that involve promoting Qi circulation,dispelling blood stasis,resolving phlegm,and replenishing kidney function.The ultimate goal is to expel toxins and alleviate symptoms.This theory establishes a solid theoretical foundation for future experimental validation and clinical approaches.

关 键 词：中医 药邪 激素 激素性股骨头坏死 病机 

分 类 号：R274.9[医药卫生—中西医结合]