鼻咽癌患者18F-FDG PET/CT代谢参数与临床病理特征的关系及对局部复发的预测价值  

Relationship between 18F-FDG PET/C T Metabolic Parameters and Clinicopathological Features in Patients with Nasopharyngeal Carcinoma and Their Predictive Value for Local Recurrence

作　　者：刘炎富 陆菊青 林霄[1] 姜秋兰[1] 吴英宁[1] 肖子正 LIU Yan-fu;LU Ju-qing;LIN Xiao;JIANG Qiu-lan;WU Ying-ning;XIAO Zi-zheng(Department of Nuclear Medicine,Affiliated Hospital of Youjiang Medical University for Nationalities,Baise 533000,the Guangxi Zhuang Autonomous Region,China)

机构地区：[1]右江民族医学院附属医院核医学科,广西百色533000

出　　处：《中国CT和MRI杂志》2024年第1期45-48,共4页Chinese Journal of CT and MRI

基　　金：2020年度广西医药卫生自筹经费科研课题(20201596)。

摘　　要：目的探讨18F-脱氧葡萄糖(FDG)正电子发射计算机断层扫描(PET/CT)代谢参数与鼻咽癌患者临床病理特征的关系及其对局部复发的预测价值,为临床诊治提供可靠依据。方法选取2020年1月~2022年1月于中山大学肿瘤防治中心行放疗的200例鼻咽癌患者作为研究对象,根据治疗后6个月内复发情况分为复发组(n=85)、未复发组(n=115)。比较两组临床病理特征及18F-FDG PET/CT代谢参数。分析不同参数与临床病理特征的关系及其对局部复发的预测价值。分析各参数不同表达者局部复发的危险度。结果复发组临床分期Ⅰ~Ⅱ期比例低于未复发组,淋巴结转移比例及18F-FDG PET/CT代谢参数最大标准摄取值(SUVmax)、平均标准摄取值(SUVmean)、峰值标准摄取值(SUVpeak)、病灶糖酵解总量(TLG)、肿瘤代谢体积(MTV)高于未复发组(P<0.05);SUVmax、MTV、TLG与临床分期、淋巴结转移呈正相关(P<0.05);SUVmax、SUVpeak、SUVmean、MTV、TLG联合预测局部复发的AUC高于单项预测(P<0.05);各参数高水平者局部复发风险分别是低水平的2.406倍、3.189倍、2.374倍、3.102倍、4.170倍。结论18F-FDG PET/CT代谢参数SUVmax、MTV、TLG与鼻咽癌患者临床病理特征具有相关性,其与SUVpeak、SUVmean联合预测局部复发具有一定预测价值。Objective To investigate the relationship between 18F-deoxyglucose(FDG)positron emission computed tomography(PET/CT)metabolic parameters and clinicopathological characteristics of patients with nasopharyngeal carcinoma and its predictive value for local recurrence,and to provide a reliable basis for clinical diagnosis and treatment.Methods Two hundred patients with nasopharyngeal carcinoma who underwent radiotherapy Sun Yat-sen University Cancer Center from January 2020 to January 2022 were selected as study subjects and divided into recurrence group(n=85)and non-recurrence group(n=115)according to their recurrence within 6 months after treatment.Clinicopathological characteristics and 18F-FDG PET/CT metabolic parameters were compared between the two groups.The relationship between different parameters and clinicopathological features and their predictive value for local recurrence were analyzed.To analyze the risk of local recurrence in those with different expression of each parameter.Results The proportion of clinical stage I to II in the recurrence group was lower than that in the non-recurrence group,and the proportion of lymph node metastasis and 18F-FDG PET/CT metabolic parameters maximum standardized uptake value(SUVmax),mean standardized uptake value(SUVmean),peak standardized uptake value(SUVpeak),total glycolysis of the lesion(TLG),and tumor metabolic volume(MTV)were higher than those in the non-recurrence group(P<0.05).SUVmax,MTV,and TLG were positively correlated with clinical stage and lymph node metastasis(P<0.05);the AUC of local recurrence predicted by the combination of SUVmax,SUVpeak,SUVmean,MTV,and TLG was higher than that of single prediction(P<0.05);the risk of local recurrence was 2.406 times,3.189 times,and 4.170 times higher for high levels of each parameter than for low levels,respectively.2.374 times,3.102 times,and 4.170 times for high levels of each parameter,respectively.Conclusion The 18F-FDG PET/CT metabolic parameters SUVmax,MTV,and TLG correlate with the clinicopathological chara

关 键 词：鼻咽癌 正电子发射断层成像 18F-脱氧葡萄糖 临床病理特征 复发 

分 类 号：R766.3[医药卫生—耳鼻咽喉科]