天麻花茎的化学成分研究  

Chemical composition of flower stem of Gastrodia elata

作　　者：秦诗慧 吴丝雨 杨柳 许凤清 胡江苗 QIN Shi-hui;WU Si-yu;YANG Liu;XU Feng-qing;HU Jiang-miao(College of Pharmacy,Anhui University of Chinese Medicine,Hefei 230012,China;State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,China)

机构地区：[1]安徽中医药大学药学院,安徽合肥230012 [2]植物化学与西部植物资源持续利用国家重点实验室,中国科学院植物研究所,云南昆明650201

出　　处：《中草药》2023年第23期7717-7722,共6页Chinese Traditional and Herbal Drugs

基　　金：中科院扶贫专项(KFJ-FP-201905)。

摘　　要：目的 研究天麻Gastrodia elata花茎的化学成分。方法 利用硅胶、Sephadex LH-20等各种色谱技术进行分离纯化,通过核磁图谱、IR、UV、质谱等多种方法并结合文献对分离得到的化合物进行结构鉴定。结果 从天麻花茎95%乙醇提取物的醋酸乙酯萃取物中分离得到13个化合物,分别鉴定为(S)-6,12-二羟基-9-甲氧基-3,3-二甲基-8,9-二氢-3H,7H-苯并[2,3]氧杂?并[4,5-b]吡喃并[2,3-h]苯并吡喃-7-酮(1)、2-(2,4-二羟基苯基)-5-羟基-3-(2-羟基-3-甲基丁-3-烯-1-基)-8,8-二甲基-4H,8H-吡喃并[2,3-f]苯并吡喃-4-酮(2)、桑黄酮C(3)、黑桑素H(4)、新环桑色烯(5)、morusin hydroperoxide(6)、桑辛素(7)、licofavone C(8)、环桑素(9)、交链孢酚(10)、3,4-dihydroxy-benzoic(11)、对羟基苯甲醇(12)、N-trans-grossamide(13)。结论 化合物1为新化合物,命名为降环桑色烯;化合物2~9为首次从该植物中分离得到。Objective To study the chemical composition of Tianma(Gastrodia elata Bl.)flower stem.Methods Various chromatographic techniques such as silica gel and Sephadex LH-20 were used for separation and purification.Various spectroscopic methods,including nuclear magnetic resonance spectrum,IR,UV,and MS,combined comparison with literatures were employed to identify the structure of the separated compounds.Results A total of 13 compounds were isolated from ethyl acetate extract in the stem of Gastrodia elata,and identified as(S)-6,12-dihydroxy-9-methoxy-3,3-dimethyl-8,9-dihydro-3H,7H-benzo[2,3]oxepino[4,5-b]pyrano[2,3-h]chromen-7-one 2,3-dihydrooxepin(1),2-(2,4-dihydroxyphenyl)-5-hydroxy-3-(2-hydroxy-3-methylbut-3-en-1-yl)-8,8-dimethyl-4H,8H-pyrano[2,3-f]chromen-4-one(2),kuwanon C(3),mornigrol H(4),neocyclomorusin(5),morusin hydroperoxide(6),morusin(7),licofavonec(8),cyclomulberrin(9),alternariol(10),3,4-dihydroxy-benzoic(11),gastrodigenin(12),and N-transgrossamide(13).Conclusion Compound 1 is identified as a novel compound and named degracyclomorusin.Compounds 2—9 are isolated from this plant for the first time.

关 键 词：天麻 降环桑色烯 黑桑素H 环桑素 桑辛素 

分 类 号：R284.1[医药卫生—中药学]