甲基莲心碱的药理作用研究进展  

Research progress on pharmacological effects of neferine

作　　者：李连雨 游秋云 陈林霖 LI Lian-yu;YOU Qiu-yun;CHEN Lin-lin(Key Laboratory of Chinese Medicine Resource and Compound Prescription,Ministry of Education,Hubei University of Chinese Medicine,Wuhan 430065,China;School of Pharmacy,Hubei University of Chinese Medicine,Wuhan 430065,China;Hubei Shizhen Laboratory,Wuhan 430065,China)

机构地区：[1]湖北中医药大学中药资源与中药复方教育部重点实验室,湖北武汉430065 [2]湖北中医药大学药学院,湖北武汉430065 [3]湖北时珍实验室,湖北武汉430065

出　　处：《中草药》2023年第23期7862-7873,共12页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金重点项目(82130119)。

摘　　要：甲基莲心碱是从睡莲科植物莲Nelumbo nucifera的种子幼叶和胚根(莲子心)中分离得到的一种具有双苄基异喹啉特殊结构的生物碱,大量研究表明其具有抗炎、抗氧化、抗肿瘤、抗心律失常、抗血栓、降压和减肥消脂等多种生物活性,在肿瘤、心血管和神经退行性疾病领域有广阔的应用前景。通过对甲基莲心碱在不同细胞和动物模型中的药理作用及作用机制进行综述,为进一步阐明甲基莲心碱的药用价值和合理开发应用提供科学依据。Neferine,a bisbenzyl isoquinoline alkaloid isolated from the young leaves and radicle(lotus plumule)of Nelumbinis Plumula,was reported to possess anti-inflammatory,antioxidant,antitumor,antiarrhythmic,antithrombotic,antihypertensive and antiobesitic activities,which has a good prospect in treating tumors,cardiovascular and neurodegenerative diseases.This article reviews the pharmacological effects and mechanisms of neferine in different cells and animal models,which provides scientific basis for further elucidating the medicinal value and rational development and application of neferine.

关 键 词：甲基莲心碱 抗肿瘤 心血管保护 神经保护 抗炎 抗氧化 

分 类 号：R285[医药卫生—中药学]