灵芝孢子粉化学成分和药理作用的研究进展及其质量标志物(Q-Marker)预测分析  

Research progress on chemical composition and pharmacological effects of Ganoderma lucidum spore and prediction analysis of quality marker

作　　者：王美丹 胡扬[1,2,3] 宋辉 孙向明[1,2] 祝嗣臣 徐蓓蕾 李文兰 WANG Mei-dan;HU Yang;SONG Hui;SUN Xiang-ming;ZHU Si-chen;XU Bei-lei;LI Wen-lan(School of Pharmacy,Harbin University of Commerce,Harbin 150076,China;Engineering Research Center of Natural Anti-cancer Drugs,Ministry of Education,Harbin 150076,China;Heilongjiang Key Laboratory of Preventive and Therapeutic Drug Research of Senile Diseases,Harbin 150076,China;Heilongjiang Kunjian Agriculture Co.,Ltd.,Qiqihar 161200,China)

机构地区：[1]哈尔滨商业大学药学院,黑龙江哈尔滨150076 [2]抗肿瘤天然药物教育部工程研究中心,黑龙江哈尔滨150076 [3]黑龙江省预防与治疗老年性疾病药物研究重点实验室,黑龙江哈尔滨150076 [4]黑龙江坤健农业股份有限公司,黑龙江齐齐哈尔161200

出　　处：《中草药》2023年第23期7918-7933,共16页Chinese Traditional and Herbal Drugs

基　　金：中央支持地方高校改革发展资金人才培养项目。

摘　　要：灵芝孢子粉是灵芝的生殖细胞,包含灵芝所有的化学成分,主要含有灵芝三萜类、多糖类、甾体类、脂肪酸类和蛋白质类等多种化合物。灵芝孢子粉具有抗肿瘤、免疫调节、抗氧化、保护心血管、保肝护肝等药理作用。《中国药典》2020年版对灵芝孢子粉的质量控制标准尚未明确规定,就灵芝孢子粉化学成分和药理作用研究进展进行综述,并基于质量标志物(quality marker,Q-Marker)理论,从植物亲缘性与特有性、有效性、可测性、临床应用、可入血成分等方面进行Q-Marker预测分析,初步推测多糖类、灵芝酸、甾醇类(麦角甾醇)、不饱和脂肪酸(油酸)等成分为其Q-Marker,为规范灵芝孢子粉质量研究和建立、完善灵芝孢子粉质量标准提供参考。Ganoderma lucidum spore is the germ cells of Lingzhi(Ganoderma),which contains all the chemical components of G.lucidum,mainly containing various compounds such as triterpenoids,polysaccharides,steroids,fatty acids and proteins.G.lucidum spore has anti-tumor,immune regulation,antioxidant,heart protection,blood sugar and lipid regulation,liver protection and other pharmacological effects.The quality control standard of G.lucidum spore has not been clearly stipulated in the 2020 edition of Chinese Pharmacopoeia.This paper summarized the research progress of the chemical composition and pharmacological action of G.lucidum spore,and based on the theory of quality marker(Q-marker),Q-markers were predicted and analyzed from the aspects of plant relatedness and specificity,effectiveness,measureability,clinical application and blood entry components.It was speculated that the ingredients of polysaccharides,ganoderma acid,sterols(ergosterol),unsaturated fatty acids(oleic acid)and so on were Q-markers,which provided reference for the standardization of G.lucidum spore quality research,establishment and improvement of G.lucidum spore quality standard.

关 键 词：灵芝孢子粉 灵芝 质量标志物 质量标准 三萜类 多糖类 

分 类 号：R284[医药卫生—中药学] R285[医药卫生—中医学]