机械张力诱发皮肤瘢痕增生的信号机制研究进展  

Signal mechanism of skin scar hyperplasia induced by mechanical tension

作　　者：蒋敏 张家平 Jiang Min;Zhang Jiaping(Department of Plastic Surgery,State Key Laboratory of Trauma,Burns and Combined Injury,the First Affiliated Hospital of Army Medical University(the Third Military Medical University),Chongqing 400038,China)

机构地区：[1]陆军军医大学(第三军医大学)第一附属医院整形外科,创伤、烧伤与复合伤国家重点实验室,重庆400038

出　　处：《中华整形外科杂志》2023年第12期1377-1383,共7页Chinese Journal of Plastic Surgery

基　　金：国家自然科学基金(82272285)。

摘　　要：外科手术后,手术部位不可避免地会留下瘢痕,了解瘢痕形成的影响因素和作用机制对改善术后外观非常重要。机械张力是影响瘢痕形成的重要因素之一。该文就机械张力影响皮肤瘢痕形成中的作用和信号机制进行归纳总结,如整合素-细胞骨架信号通路、转化生长因子-β信号通路、Hippo信号通路、Rho相关途径、机械敏感离子通道途径等,为进一步研究提供参考。After surgery,scars will inevitably be left at the surgical site.It is very important to understand the influencing factors and mechanism of scars formation to improve postoperative appearance.Mechanical tension is one of the important factors affecting scar formation.In this paper,the effects and signaling mechanisms of mechanical tension on scar formation,such as integrin-cytoskeleton signal pathway,transforming growth factor-βsignal pathway,Hippo signal pathway,Rho-related pathway,mechanically sensitive ion channel pathway and so on,were summarized to provide reference for further research.

关 键 词：瘢痕 增生 机械张力 信号通路 

分 类 号：R622[医药卫生—整形外科]