血清性激素结合球蛋白水平与中国成年男性代谢综合征及其组分发生风险的相关性研究  

Study on the associations of serum sex hormone-binding globulin levels with the prevalence of metabolic syndrome and its components in Chinese adult men

作　　者：刘彦玲 马晓君[1] 宋怡 王娇[1] 薄楠楠 秦贵军[1] Liu Yanling;Ma xiaojun;Song Yi;Wang jiao;Bo nannan;Qin Guijun(Department of Endocrinology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;College of Arts and Sciences,University of Washington-Seattle,Seattle 98104,USA)

机构地区：[1]郑州大学第一附属医院内分泌科,郑州450052 [2]华盛顿大学西雅图分校文理学院,美国西雅图98104

出　　处：《国际内分泌代谢杂志》2023年第6期459-463,468,共6页International Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金面上项目(82170839)。

摘　　要：目的探讨中国成年男性性激素结合球蛋白(sex hormone-binding globulin,SHBG)水平与代谢综合征(metabolic syndrome,MS)及其组分发生风险之间的相关性。方法2015年12月至2016年3月,采用多阶段分层整群随机抽样法从甲状腺疾病和糖尿病全国调查-2014河南分中心调查队列中抽取1230例男性受试者,记录一般临床资料,检测血清SHBG、性激素、血脂、血糖等指标。根据SHBG水平的四分位分为4组,分析受试者血清SHBG水平与MS及其各组分的相关性。结果与SHBG最低四分位组相比,随着SHBG水平升高,MS患病率呈逐渐降低趋势。SHBG与除高血压外的所有MS组分患病率呈负相关,但进一步校正年龄、生活方式和总睾酮后,SHBG仅与腹型肥胖及高甘油三脂血症呈显著负相关。结论血清SHBG与中国成年男性MS发生风险、腹型肥胖和高甘油三脂血症发生风险呈显著负相关,独立于年龄、生活方式因素和血清睾酮水平。Objective To explore the associations of serum sex hormone-binding globulin(SHBG)levels with the prevalence of metabolic syndrome(MS)and its components among Chinese adult men.Methods A total of 1230 adult male were obtained from the thyroid disease,and diabetes:a national epidemiological survey-2014 research-Henan subcenter survey through multistage stratified cluster random sampling from December 2015 to March 2016.General clinical data were collected.Serum SHBG,sex hormones,blood lipids,blood glucose and other indicators were detected.The subjects were divided into four groups according to the quartiles of SHBG levels,and the correlation of serum SHBG levels with MS and its components were analyzed.Results Compared with the lowest quartile group of SHBG levels,the prevalence of MS showed a gradually decreasing trend with the increase of SHBG levels.SHBG levels were negatively associated with the prevalence of all MS components except for high blood pressure,but after further adjustment for age,lifestyle factors and total testosterone levels,the significant associations could be observed between SHBG and central obesity or increased triglyceride.Conclusion Serum SHBG levels were significantly negatively associated with the risk of MS and central obesity or increased TG in Chinese adult males,independent of age,lifestyle factors,and serum total testosterone levels.

关 键 词：性激素结合球蛋白 代谢综合征 甘油三脂 肥胖 

分 类 号：R589[医药卫生—内分泌]