2型糖尿病与脑微循环障碍关系的研究进展  

Research progress on the relationship between type 2 diabetes mellitus and cerebral microcirculation dysfunction

作　　者：徐汉文 郑佳[2] 吴春 马静[4] 张薇 Xu Hanwen;Zheng Jia;Wu Chun;Ma Jing;Zhang Wei(Department of Endocrinology,the First People's Hospital of Jiashan,Jiaxing 314100,China;Center for General Practice Medicine,Department of Nutrition,Zhejiang Provincial People's Hospital(Affiliated People's Hospital,Hangzhou Medical College),Hangzhou 310014,China;Department of Endocrinology,Tongling People's Hospital,Tongling 244099,China;State Key Laboratory of Pathogenesis,Prevention and Treatment of High Incidence Diseases in Central Asia,Department of Endocrinology,the First People's Hospital of Aksu District in Xinjiang,Aksu 843000,China)

机构地区：[1]嘉善县第一人民医院内分泌科,嘉兴314100 [2]浙江省人民医院营养科,全科医学中心,杭州医学院附属人民医院,杭州310014 [3]铜陵市人民医院,铜陵244099 [4]省部共建中亚高发病成因与防治国家重点实验室,新疆阿克苏地区第一人民医院内分泌科,阿克苏843000

出　　处：《国际内分泌代谢杂志》2023年第6期513-516,共4页International Journal of Endocrinology and Metabolism

基　　金：省部共建中亚高发病成因与防治国家重点实验室开放课题资助项目(SKL-HIDCA-2023-AY4)。

摘　　要：2型糖尿病患者发生脑卒中、认知功能障碍和抑郁的风险显著增加。这些脑部疾病的致死率及致残率高,严重危害患者的健康。近年来越来越多的证据表明脑微循环障碍可能是2型糖尿病患者发生脑卒中、认知功能障碍和抑郁的关键潜在机制之一。了解2型糖尿病与脑微循环障碍关系的研究进展,有助于2型糖尿病脑微循环障碍相关并发症的预防和治疗。本文综述了2型糖尿病脑微循环障碍的驱动因素、病理生理表现、评估方法、相关并发症和治疗方法。Patients with T2DM have a significantly increased risk of stroke,cognitive impairment,and depression.These brain diseases have a high mortality and disability rate,which seriously endangers the health of patients.In recent years,there has been increasing evidence that cerebral microcirculation dysfunction may be one of the key underlying mechanisms of stroke,cognitive dysfunction,and depression.Understanding the relationship between T2DM and cerebral microcirculation dysfunction is helpful in the prevention and treatment of cerebral microcirculation dysfunction complications in patients with T2DM.Therefore,this article reviews the driving factors,pathophysiological manifestations,evaluation methods,related complications and treatment methods of cerebral microcirculation dysfunction in T2DM.

关 键 词：2型糖尿病 微循环 脑微循环 微血管障碍 

分 类 号：R587.1[医药卫生—内分泌]