Investigation into the epidemiology,genetic characteristics,and clinical manifestations of the first monkeypox outbreak in Shenzhen,China  

作　　者：Jia Wan Xiaomin Zhang Jing Qu Bo Peng Dongfeng Kong Jianhua Lu Qinghua Hu Zhifeng Zhou Haiduan Lin Xiangjie Yao Yulin Fu Qing Xu Ying Lin Yan Yang Jinzhen Tang Lin Lin Huimin Li Ziquan Lv Zhen Zhang Xuan Zou Xiaolu Shi 

机构地区：[1]Shenzhen Center for Disease Control and Prevention,Shenzhen 518000,China [2]Shenzhen Futian District Center for Disease Control and Prevention,Shenzhen 518000,China [3]Shenzhen Longgang District Center for Disease Control and Prevention,Shenzhen 518000,China

出　　处：《Biosafety and Health》2023年第5期259-265,共7页生物安全与健康（英文）

基　　金：the Science and Technology Planning Project of Guangdong Province of China(Grant 2021 B1212030009);Sanming Project of Medicine in Shenzhen(No.SZSM202011008);Research Foundation of Shenzhen Science and Technology Emergency Key Technology Program(JSGG20220301090007009);Shenzhen Key Medical Discipline Construction Fund(SZXK064).

摘　　要：This paper comprehensively analyses the first-ever monkeypox outbreak in Shenzhen,China,encompassing clinical symptomatology,therapeutic approaches,epidemiological research,and comprehensive laboratory tests,aiming to establish a robust reference for future monkeypox mitigation and management strategies.The investigation involved a thorough investigation of all identified positive cases,including extensive molecular analysis by nucleic acid detection and whole-genome sequencing of the monkeypox virus.Contact tracing and containment of the infected individuals were also undertaken.Three distinct monkeypox cases were identified in this unique outbreak,exhibiting mild and atypical clinical manifestations,primarily fever and rash.All cases were associated with a single transmission chain,primarily facilitated through close contact and homosexual behavior,indicative of a high-risk factor for monkeypox transmission.

关 键 词：MONKEYPOX EPIDEMIOLOGY Genetic characteristics 

分 类 号：R511[医药卫生—内科学]