血脂水平与IgA肾病患者临床病理特征及C3、C4水平的关系  

Correlations of levels of blood lipids with clinicopathological characteristics and levels of complement components C3 and C4 in patients with immunoglobulin A nephropathy

作　　者：黄玉萍[1] 徐辉 王道洋[1] 马续祥 王菡[1] 周玉叶[1] 纵晓英[1] 吴雪平[3] Huang Yu-ping;Xu Hui;Wang Dao-yang;Ma Xu-xiang;Wang Han;Zhou Yu-ye;Zong Xiao-ying;Wu Xue-ping(Department of Nephrology,Second Affiliated Hospital of Bengbu Medical College,Bengbu,Anhui 233040,China;Department of Nephrology,Huaiyuan County Hospital of Traditional Chinese Medicine,Bengbu,Anhui 233400,China;Department of Nephrology,First Affiliated Hospital of Bengbu Medical College,Bengbu,Anhui 233000,China)

机构地区：[1]蚌埠医学院第二附属医院肾内科,安徽蚌埠233040 [2]怀远县中医院肾内科,安徽蚌埠233400 [3]蚌埠医学院第一附属医院肾内科,安徽蚌埠233000

出　　处：《中国现代医学杂志》2023年第24期7-11,共5页China Journal of Modern Medicine

基　　金：蚌埠医学院转化医学重点专项(No:BYTM2019033)。

摘　　要：目的 探讨血脂水平与IgA肾病(IgAN)患者临床病理特征及补体3、4(C3、C4)水平的关系。方法选取2018年1月—2021年12月在蚌埠医学院第一、二附属医院肾脏内科行肾活检诊断为IgAN的119例患者为研究对象,根据血脂水平将其分为异常组(84例)[甘油三酯(TG)≥2.26 mmol/L和/或总胆固醇(TC)≥6.22 mmol/L和/或高密度脂蛋白(HDL)<1.04 mmol/L]、正常组(35例),比较两组患者临床病理特征,采用Pearson法分析血脂(TG、TC、HDL)与C3、C4水平的相关性。结果 异常组与正常组患者年龄、性别构成、收缩压、舒张压、血红蛋白、白蛋白、血肌酐、eGFR、血尿素氮、血尿酸、24 h尿蛋白、尿红细胞计数、CKD分期、肾小球球性硬化、肾小管萎缩面积、小球新月体、间质血管损伤程度、炎症细胞浸润及Lee氏分级比较,差异均无统计学意义(P>0.05)。异常组BMI、C3、C4水平高于正常组(P <0.05)。IgAN患者血清TG与C4呈正相关(r=0.247,P <0.05),与C3无相关性(r=0.102,P>0.05);血清TC与C4呈正相关(r=0.240,P <0.05),与C3无相关性(r=0.029,P>0.05);血清HDL与C3、C4无相关性(r=0.080和0.171,均P>0.05)。结论 部分IgAN患者存在血脂水平异常,且其血清TG、TC与C4水平呈正相关。Objective To explore the correlations of levels of blood lipids with clinicopathological characteristics and levels of complement components C3 and C4 in patients with immunoglobulin A nephropathy(IgAN).Methods One hundred and nineteen patients with IgAN diagnosed by renal biopsy in the Department of Nephrology of the First and Second Affiliated Hospital of Bengbu Medical College from January 2018 to December 2021 were selected.They were divided into abnormal group[levels of triacylglycerol(TG)≥2.26 mmol/L and/or total cholesterol(TC)≥6.22 mmol/L and/or high-density lipoprotein(HDL)<1.04 mmol/L,n=84]and normal group(n=35)according to the levels of blood lipids.The clinicopathological characteristics of the two groups were compared.The Pearson method was applied to analyze the correlations between levels of blood lipids(TG,TC,and HDL)and levels of C3 and C4.Results There was no statistically significant difference in age,sex composition,systolic blood pressure,diastolic blood pressure,levels of hemoglobin,albumin and blood creatinine,eGFR,levels of blood urea nitrogen,blood uric acid and 24-hour urine protein,urine red blood cell count,CKD stage,glomerulosclerosis,area of renal tubular atrophy,glomerular crescent formation,degree of interstitial blood vessel injury,inflammatory cell infiltration,or histological grade assessed via Lee's grading system between the abnormal group and the normal group(P>0.05).The BMI and levels of C3 and C4 in the abnormal group were higher than those in the normal group(P<0.05).The serum level of TG was positively correlated with the level of C4(r=0.247,P<0.05),but was not correlated with the level of C3(r=0.102,P>0.05).The serum level of TC was positively correlated with the level of C4(r=0.240,P<0.05),but was not correlated with the level of C3(r=0.029,P>0.05).There was no correlation between the serum level of HDL and levels of C3 and C4(r=0.080 and 0.171,P>0.05).Conclusions Some patients with IgA nephropathy exhibit abnormal levels of blood lipids,and serum levels of TG and T

关 键 词：IGA肾病 血脂 临床病理特征 补体3 补体4 

分 类 号：R692.6[医药卫生—泌尿科学] R322.61[医药卫生—外科学]