狼疮性肾炎患者尿液miR-26a、miR-146a表达及对病情活动的预测价值分析  

Expression of urine miR-26a and miR-146a in patients with lupus nephritis and predictive value for disease activity

作　　者：杨晓芳 赵苘 丰文君 YANG Xiaofang;ZHAO Qing;FENG Wenjun(Nephrology Medicine Department,Zhengzhou Yihe Hospital,Zhengzhou 450047,China)

机构地区：[1]郑州颐和医院肾病医学科,河南郑州450047

出　　处：《临床医学研究与实践》2024年第2期33-37,共5页Clinical Research and Practice

摘　　要：目的 分析狼疮性肾炎(LN)患者尿液miR-26a、miR-146a表达及对病情活动的预测价值。方法 选取2021年1月至2022年12月在本院住院的158例LN患者,按照系统性红斑狼疮活动指数(SLEDAI)将其分为LN稳定期组(88例)和LN活动期组(70例);选取同期本院60例体检健康者作为对照组。比较三组的一般资料及常规实验室指标;用多因素Logistic回归分析影响LN病情活动的因素;分析LN患者尿液miR-26a、miR-146a预测病情活动的效能。结果 LN活动期组和LN稳定期组的补体C3、补体C4、血红蛋白、白蛋白水平及尿液miR-26a、miR-146a表达量均低于对照组,差异具有统计学意义(P<0.05)。LN活动期组的补体C4、血红蛋白、白蛋白水平及尿液miR-26a、miR-146a表达量均低于LN稳定期组,尿酸水平高于LN稳定期组(P<0.05)。多因素Logistic回归分析显示,尿液miR-26a、miR-146a均是影响LN患者病情活动的因素(P<0.05)。尿液miR-26a、miR-146a及二者联合预测LN患者病情活动的曲线下面积(AUC)分别为0.773、0.686、0.876;二者联合预测价值优于尿液miR-26a及miR-146a单独预测(P=0.037、0.000)。结论 miR-26a及miR-146a在LN患者尿液中表达降低,二者联合用于预测LN病情活动的价值更高。Objective To analyze the expression of urine miR-26a and miR-146a in patients with lupus nephritis(LN)and predictive value for disease activity.Methods A total of 158 LN patients who were hospitalized in our hospital from January 2021 to December 2022 were selected and divided into LN stable group(88 cases)and LN active group(70 cases)according to systemic lupus erythematosis disease activity index(SLEDAI),60 cases healthy people who underwent physical examination in our hospital during the same period were selected as the control group.The general data and routine laboratory indexes of the three groups were compared.Multivariate Logistic regression analysis was used to analyze the factors affecting the activity of LN.The efficacy of urine miR-26a and miR-146a in predicting disease activity in LN patients was analyzed.Results The levels of complement C3,complement C4,hemoglobin,albumin,and the expressions of urine miR-26a and miR-146a in the LN active group and the LN stable group were lower than those in the control group,the differences were statistically significant(P<0.05).The levels of complement C4,hemoglobin,albumin,and the expressions of urine miR-26a and miR-146a in the LN active group were lower than those in the LN stable group,and the uric acid level was higher than that in the LN stable group(P<0.05).Multivariate Logistic regression analysis showed that urine miR-26a and miR-146a were the factors affecting the disease activity of LN patients(P<0.05).The receiver operating characteristic(AUC)of urine miR-26a,miR-146a and the combination of the two in predicting the disease activity of LN patients were 0.773,0.686 and 0.876,respectively.The combined predictive value was better than that of urine miR-26a and miR-146a alone predictive(P=0.037,0.000).Conclusion The expression of miR-26a and miR-146a in the urine of LN patients is decreased,and the combination of the two is more valuable in predicting the disease activity of LN.

关 键 词：狼疮性肾炎 miRNA-26a miRNA-146a 尿液 病情活动 

分 类 号：R593.24[医药卫生—内科学]