美罗培南不同给药途径治疗颅脑损伤术后颅内感染患者的效果及对预后的影响  

Effect of different administration routes of meropenem in the treatment of patients with postoperative intracranial infection after craniocerebral injury and its influence on prognosis

作　　者：张雨晨 李媛[2] ZHANG Yuchen;LI Yuan(Pharmacy Department,the Affiliated Hospital of Northwest University/Xi'an No.3 Hospital,Xi'an 710018;Pharmacy Department,Xi'an Children's Hospital,Xi'an 710003,China)

机构地区：[1]西北大学附属医院/西安市第三医院药剂科,陕西西安710018 [2]西安市儿童医院药剂科,陕西西安710003

出　　处：《临床医学研究与实践》2024年第2期46-49,共4页Clinical Research and Practice

基　　金：陕西省自然科学基础研究计划项目(No.2023-JC-QN-0832)。

摘　　要：目的 分析美罗培南不同给药途径治疗颅脑损伤术后颅内感染患者的效果及对预后的影响。方法 选取2020年1月至2023年12月收治的90例颅脑损伤术后颅内感染患者为研究对象,根据美罗培南不同给药途径将其分为常规组(23例,常规静脉滴注)和观察组(67例,常规静脉滴注+脑室内注射)。比较两组的治疗效果。结果 观察组的治疗总有效率高于常规组(P<0.05)。观察组的脑室外引流管留置时长、静脉用药时长短于常规组(P<0.05)。治疗后,观察组的C反应蛋白(CRP)、白细胞介素-6(IL-6)、白细胞介素-34(IL-34)、降钙素原(PCT)水平及白细胞计数(WBC)低于常规组(P<0.05)。治疗后,观察组的CD4^(+)、CD4^(+)/CD8^(+)高于常规组,CD8^(+)低于常规组,差异具有统计学意义(P<0.05)。两组的不良反应总发生率无显著差异(P>0.05)。结论美罗培南常规静脉滴注+脑室内注射给药途径治疗颅脑损伤术后颅内感染患者可取得理想效果与预后保障。Objective To analyze the effect of different administration routes of meropenem in the treatment of patients with postoperative intracranial infection after craniocerebral injury and its influence on prognosis.Methods From January 2020 to December 2023,90 patients with postoperative intracranial infection after craniocerebral injury were selected as the research objects.The patients were divided into routine group(23 cases,routine intravenous drip)and observation group(67 cases,routine intravenous drip + intraventricular injection)by different administration routes of meropenem.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the routine group(P<0.05).The indwelling time of external ventricular drainage tube and the duration of intravenous medication in the observation group were shorter than those in the routine group(P<0.05).After treatment,the levels of C-reactive protein(CRP),interleukin-6(IL-6),interleukin-34(IL-34),procalcitonin(PCT)and white blood cell(WBC)in the observation group were lower than those in the routine group(P<0.05).After treatment,CD4^(+)and CD4^(+)/CD8^(+)in the observation group were higher than those in the routine group,and CD8^(+)was lower than that in the routine group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Meropenem routine intravenous drip+intraventricular injection can achieve ideal curative effect and prognosis guarantee in the treatment of patients with postoperative intracranial infection after craniocerebral injury.

关 键 词：美罗培南 静脉滴注 脑室内注射 颅脑损伤 术后颅内感染 

分 类 号：R651.15[医药卫生—外科学]