沙库巴曲缬沙坦治疗维持性血液透析合并慢性心力衰竭患者的临床效果  

Clinical effect of sacubitril/valsartan in the treatment of maintenance hemodialysis patients with chronic heart failure

作　　者：姚转娥 王鹏波 付秦娟 宋琼 刘爱 张鹏[2] YAO Zhuan'e;WANG Pengbo;FU Qinjuan;SONG Qiong;LIU Ai;ZHANG Peng(Shaanxi Provincial Second People's Hospital,Xi'an 710005;Xijing Hospital,Xi'an 710000,China)

机构地区：[1]陕西省第二人民医院,陕西西安710005 [2]西京医院,陕西西安710000

出　　处：《临床医学研究与实践》2024年第2期54-57,共4页Clinical Research and Practice

基　　金：陕西省卫生健康科研基金项目(No.2022E013)。

摘　　要：目的探讨沙库巴曲缬沙坦治疗维持性血液透析合并慢性心力衰竭患者的有效性和安全性。方法选取在陕西省第二人民医院血液净化中心行维持性血液透析且合并慢性心力衰竭的21例患者为研究对象,均给予沙库巴曲缬沙坦治疗12周。比较治疗前、后的生命体征、生化指标、心功能指标、生活质量及不良反应发生情况。结果治疗后,维持性血液透析合并慢性心力衰竭患者的收缩压、舒张压、纽约心脏病学会(NYHA)分级Ⅲ级占比、N末端B型脑钠肽前体(NT-proBNP)水平低于治疗前,左室射血分数(LVEF)高于治疗前,左室舒张末期内径(LVDD)、左室收缩末期内径(LVDS)小于治疗前(P<0.05)。治疗后,维持性血液透析合并慢性心力衰竭患者的躯体健康、精神健康评分高于治疗前(P<0.001)。结论沙库巴曲缬沙坦有利于改善维持性血液透析合并慢性心力衰竭患者的心功能及生活质量。Objective To investigate the efficacy and safety of sacubitril/valsartan in the treatment of maintenance hemodialysis patients with chronic heart failure.Methods Twenty-one patients with maintenance hemodialysis complicated with chronic heart failure in the blood purification center of Shaanxi Provincial Second People's Hospital were selected as the study objects.All patients were treated with sacubitril/valsartan for 12 weeks.The vital signs,biochemical indexes,cardiac function indexes,quality of life and adverse reactions before and after treatment were compared.Results After treatment,the systolic blood pressure,diastolic blood pressure,proportion of New York Heart Association(NYHA)gradeⅢ,and N-terminal pro-brain natriuretic peptide(NT-proBNP)level in patients with maintenance hemodialysis complicated with chronic heart failure were lower than those before treatment,left ventricular ejection fraction(LVEF)was higher than that before treatment,while left ventricular end-diastolic diameter(LVDD)and left ventricular end-systolic dimension(LVDS)were less than those before treatment(P<0.05).After treatment,the scores of physical health and mental health in patients with maintenance hemodialysis complicated with chronic heart failure were higher than those before treatment(P<0.001).Conclusion Sacubitril/valsartan is beneficial to improve cardiac function and quality of life in patients with maintenance hemodialysis complicated with chronic heart failure.

关 键 词：血液透析 慢性心力衰竭 沙库巴曲缬沙坦 心功能 生活质量 

分 类 号：R541.6[医药卫生—心血管疾病]