血必净注射液联合连续性肾替代疗法、白蛋白治疗肾综合征出血热的效果及对炎性因子、相关蛋白表达的影响  

Effect of Xuebijing injection combined with continuous renal replacement therapy and albumin in the treatment of hemorrhagic fever with renal syndrome and its influences on the inflammatory factors and expression of related proteins

作　　者：贾庶捷 张倩落 李燕平 任健 杨海敏 JIA Shujie;ZHANG Qianluo;LI Yanping;REN Jian;YANG Haimin(Pharmacy Department;Infection Department,Xi'an Eighth Hospital,Xi'an 710061,China)

机构地区：[1]西安市第八医院药剂科,陕西西安710061 [2]西安市第八医院感染科,陕西西安710061

出　　处：《临床医学研究与实践》2024年第2期58-61,共4页Clinical Research and Practice

基　　金：西安市科技计划项目(No.21YXYJ0063)。

摘　　要：目的 探讨血必净注射液联合连续性肾替代疗法、白蛋白治疗肾综合征出血热的效果。方法 选取2022年1月至5月收治的50例肾综合征出血热患者为研究对象,根据随机数字表法将其分为对照组和观察组,各25例。对照组采用连续性肾替代疗法、白蛋白治疗,观察组在对照组基础上联合血必净注射液治疗。比较两组的治疗效果。结果 观察组的治疗总有效率高于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的CD61、热休克蛋白70(HSP70)低于对照组,差异具有统计学意义(P<0.05)。结论 血必净注射液联合连续性肾替代疗法、白蛋白治疗肾综合征出血热的效果显著,可改善炎性因子水平,下调CD61、HSP70表达,值得推广及应用。Objective To investigate the effect of Xuebijing injection combined with continuous renal replacement therapy and albumin in the treatment of hemorrhagic fever with renal syndrome.Methods A total of 50 patients with hemorrhagic fever with renal syndrome admitted from January to May 2022 were selected as the research objects.According to the random number table method,the patients were divided into control group and observation group,with 25 cases in each group.The control group was treated with continuous renal replacement therapy and albumin,and the observation group was treated with Xuebijing injection on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,CD61 and heat shock protein 70(HSP70)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Xuebijing injection combined with continuous renal replacement therapy and albumin in the treatment of hemorrhagic fever with renal syndrome has a significant effect,it can improve the levels of inflammatory factors,and down-regulate the expression of CD61 and HSP70,which is worthy of promotion and application.

关 键 词：血必净注射液 连续性肾替代疗法 白蛋白 肾综合征出血热 炎性因子 

分 类 号：R692.5[医药卫生—泌尿科学]