乙酰半胱氨酸联合持续气道正压通气无创呼吸机对中重度阻塞性睡眠呼吸暂停低通气综合征患者血气指标及睡眠状态的影响  

Effects of acetylcysteine combined with continuous positive airway pressure noninvasive ventilator on blood gas index and sleep state in patients with moderate to severe obstructive sleep apnea hypopnea syndrome

作　　者：韩芳芳 韩晓惠 HAN Fangfang;HAN Xiaohui(Xunyi County Hospital,Xianyang 711300,China)

机构地区：[1]旬邑县医院,陕西咸阳711300

出　　处：《临床医学研究与实践》2024年第2期66-69,共4页Clinical Research and Practice

摘　　要：目的 探讨乙酰半胱氨酸联合持续气道正压通气无创呼吸机治疗中重度阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的效果。方法 选取2017年1月至2022年1月我院收治的90例中重度OSAHS患者为研究对象,按照随机数字表法将其分为对照组与观察组,各45例。对照组给予持续气道正压通气无创呼吸机治疗,观察组在对照组基础上加用乙酰半胱氨酸治疗。比较两组的治疗效果。结果 治疗后,观察组的二氧化碳分压(PaCO_(2))低于对照组,氧分压(PaO_(2))、血氧饱和度(SaO_(2))高于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的震荡频率为5 Hz时的黏性阻力(R5)、震荡频率为5 Hz时呼吸总阻抗(Z5)、震荡频率为20 Hz时中心气道黏性阻力(R20)低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的觉醒次数少于对照组,深睡眠时间、快动眼睡眠(REM)时间长于对照组,差异具有统计学意义(P<0.05)。结论 乙酰半胱氨酸联合持续气道正压通气无创呼吸机治疗中重度OSAHS,不仅能够调节患者的血气指标,还能降低气道阻力,改善睡眠状态。Objective To explore the effect of acetylcysteine combined with continuous positive airway pressure noninvasive ventilator in the treatment of moderate to severe obstructive sleep apnea hypopnea syndrome(OSAHS).Methods A total of 90 patients with moderate to severe OSAHS admitted in our hospital from January 2017 to January 2022 were selected as the research objects.According to the random number table method,the patients were divided into control group and observation group,with 45 cases in each group.The control group was treated with continuous positive airway pressure noninvasive ventilator,and the observation group was treated with acetylcysteine on the basis of the control group.The therapeutic effects of the two groups were compared.Results After treatment,the partial pressure of carbon dioxide(PaCO_(2))in the observation group was lower than that in the control group,and the partial pressure of oxygen(PaO_(2))and the blood oxygen saturation(SaO_(2))were higher than those in the control group,the differences were statistically significant(P<0.05).After treatment,the respiratory resistance at 5 Hz(R5),oscillation frequency total respiratory impedance at 5 Hz(Z5)and central airway viscosity resistance at 20 Hz oscillation frequency(R20)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the number of awakenings in the observation group was less than that in the control group,and the deep sleep time and rapid eye movement(REM)time were longer than those in the control group,the differences were statistically significant(P<0.05).Conclusion Acetylcysteine combined with continuous positive airway pressure noninvasive ventilator in the treatment of moderate to severe OSAHS can not only regulate the blood gas index of patients,but also reduce airway resistance and improve sleep status.

关 键 词：乙酰半胱氨酸 持续气道正压通气无创呼吸机 阻塞性睡眠呼吸暂停低通气综合征 

分 类 号：R766[医药卫生—耳鼻咽喉科]