芪地桃蛭二蝉方联合他克莫司治疗膜性肾病的效果及对血清PLA2R、BAFF、IL-6水平的影响  

Effect of Qidi Taozhi Erchan recipe combined with tacrolimus in the treatment of membranous nephropathy and its influences on serum PLA2R,BAFF and IL-6 levels

作　　者：郭亚平 郭补林 刘旭琴 鲁小庆 赵亚峰 GUO Yaping;GUO Bulin;LIU Xuqin;LU Xiaoqing;ZHAO Yafeng(Traditional Chinese Medicine Hospital of Yulin,Yulin 719000;Shaanxi Traditional Chinese Medicine Hospital,Xi'an 710003,China)

机构地区：[1]榆林市中医医院,陕西榆林719000 [2]陕西省中医医院,陕西西安710003

出　　处：《临床医学研究与实践》2024年第2期109-112,共4页Clinical Research and Practice

基　　金：2022年陕西省中医药管理局项目(No.SZY-NLTL-2022-036);2019年榆林市科学技术研究与开发项目(No.2019-52);2019年榆林市科学技术协会“青年人才托举计划”专项(No.20190117)。

摘　　要：目的 探究芪地桃蛭二蝉方联合他克莫司治疗膜性肾病的效果及对抗磷脂酶A2受体(PLA2R)、B淋巴细胞活化因子(BAFF)及白细胞介素-6(IL-6)水平的影响。方法 选取2017年11月至2020年4月收治的84例膜性肾病患者为研究对象,将其随机分为对照组与联合组,各42例。对照组给予基础治疗加他克莫司治疗,联合组在对照组基础上加芪地桃蛭二蝉方治疗。比较两组的治疗效果。结果 联合组的治疗总有效率高于对照组,差异具有统计学意义(P<0.05)。治疗前,两组的24 h尿蛋白定量(24 h UPQ)、人血清白蛋白(HSA)、血清肌酐浓度(Scr)水平比较,差异无统计学意义(P>0.05);治疗后,两组的24 h UPQ、Scr水平均明显降低,HSA水平均明显升高,且联合组优于对照组,差异具有统计学意义(P<0.05)。治疗前,两组的PLA2R、BAFF及IL-6水平比较,差异无统计学意义(P>0.05);治疗后,两组的PLA2R、BAFF及IL-6水平均明显降低,且联合组低于对照组,差异具有统计学意义(P<0.05)。联合组的不良反应总发生率低于对照组,差异具有统计学意义(P<0.05)。结论 芪地桃蛭二蝉方联合他克莫司治疗膜性肾病效果显著,能够明显降低PLA2R、BAFF及IL-6水平,安全可靠,值得推广。Objective To explore the effect of Qidi Taozhi Erchan recipe combined with tacrolimus in the treatment of membranous nephropathy and its influences on phospholipase A2 receptor(PLA2R),B lymphocyte activating factor(BAFF)and interleukin-6(IL-6)levels.Methods A total of 84 patients with membranous nephropathy admitted from November 2017 to April 2020 were selected as the study objects,and the patients were randomly divided into control group and combined group,with 42 cases in each group.The control group was treated with basic treatment and tacrolimus,and the combined group was treated with Qidi Taozhi Erchan recipe on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the combined group was higher than that in the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of 24 hours urine protein quantification(24 h UPQ),human serum albumin(HSA)and serum creatinine concentration(Scr)between the two groups(P>0.05);after treatment,the levels of 24 h UPQ and Scr in the two groups significantly decreased,the level of HSA significantly increased,those in the combined group were better than the control group,and the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of PLA2R,BAFF and IL-6 between the two groups(P>0.05);after treatment,the levels of PLA2R,BAFF and IL-6 in the two groups significantly decreased,those in the combined group were lower than the control group,and the differences were statistically significant(P<0.05).The total incidence of adverse reactions in the combined group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Qidi Taozhi Erchan recipe combined with tacrolimus in the treatment of membranous nephropathy has a significant effect,it can significantly reduce the levels of PLA2R,BAFF and IL-6,which is safe

关 键 词：芪地桃蛭二蝉方 他克莫司 膜性肾病 抗磷脂酶A2受体 B淋巴细胞活化因子 白细胞介素-6 

分 类 号：R277.5[医药卫生—中医学]