DCE-MRI和DWI检查在术前诊断脑胶质瘤病变恶性程度中的应用价值  

The Relationship between Related Parameters and Microvessel Density in Preoperative Diagnosis of Glioma by DCE-MRI

作　　者：李晓敏 张清恒 张海三[1] LI Xiao-min;ZHANG Qing-heng;ZHANG Hai-san(Department of MRI,the Second Affiliated Hospital of Xinxiang Medical College,Xinxiang 453002,Henan Province,China;Department of NMR,The First People's Hospital of Luohe,Luohe 462000,Henan Province,China)

机构地区：[1]新乡医学院第二附属医院核磁共振科,河南新乡453002 [2]漯河市第一人民医院核磁共振科,河南漯河462000

出　　处：《罕少疾病杂志》2024年第1期16-18,共3页Journal of Rare and Uncommon Diseases

基　　金：河南医学科技攻关计划联合共建项目(LHGJ20200476)。

摘　　要：目的探究利用磁共振动态造影技术预测术前脑胶质瘤参数与微血管密度(MVD)之间的关联。方法本次选取的研究对象为我院于2012年9月~2020年5月收治的76例脑胶质瘤患者。根据世界卫生组织(WHO)的分级和脑胶质瘤的恶性程度,将患者分为低级别胶质瘤(32例)和高级别胶质瘤(44例)。对不同分级患者的(Ktrans)容积转运参数、(Ve)血管外细胞外间隙容积比、(ADC)表观扩散系数以及MVD进行比较。经ROC分析,(Ktrans值、Ve、ADC、MVD)预测高级别脑胶质瘤的意义,整理(Ktrans值、Ve、ADC与MVD)的相关性。结果低级别脑胶质瘤患者Ktrans值、Ve、MVD与高级别脑胶质瘤患者及ACD对比后,前两者对比后者属于较高的,后两者对比是后者较高的。对ROC分析中,Ktrans值、Ve、ADC、MVD对于高级的曲线下面积是(0.746、0.812、0.682、0.668)。Ktrans值和Ve与MVD之间存在正相关关系,而ADC与MVD呈现负相关。结论DCE-MRI术前可用于诊断脑胶质瘤相关参数,并显示其与患者的微血管密度(MVD)以及病变恶性程度之间的关联,为手术方案制定和预后评估提供了可靠的参考依据。Objective To explore the correlation between preoperative parameters of glioma using dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)and microvessel density(MVD).Methods This study included 76 patients with gliomas admitted to our hospital from September 2012 to May 2020.Patients were divided into low-grade glioma(32 cases)and high-grade glioma(44 cases)according to the World Health Organization(WHO)grading and the malignancy of gliomas.The comparison was made among different grades of patients in terms of parameters including volume transfer coefficient(Ktrans),extravascular extracellular volume fraction(Ve),apparent diffusion coefficient(ADC),and MVD.The significance of predicting high-grade gliomas by(Ktrans,Ve,ADC,MVD)was assessed through ROC analysis,and the correlation between(Ktrans,Ve,ADC,MVD)was summarized.Results In comparison with high-grade glioma patients and ADC,Ktrans value,Ve,and MVD of low-grade glioma patients were relatively higher,while ADC and MVD of low-grade glioma patients were relatively lower.In ROC analysis,the areas under the curve for predicting high-grade gliomas were 0.746,0.812,0.682,and 0.668 for Ktrans value,Ve,ADC,and MVD,respectively.There was a positive correlation between Ktrans value and Ve with MVD,while ADC exhibited a negative correlation with MVD.Conclusion DCE-MRI can be employed for diagnosing glioma-related parameters preoperatively and demonstrates an association with microvessel density(MVD)and the malignancy level of the lesion,providing reliable references for surgical planning and prognosis assessment.

关 键 词：磁共振动态造影技术 脑胶质细胞瘤 容积转运速率 细胞外分数容积 弥散率 微血管密度 

分 类 号：R445.2[医药卫生—影像医学与核医学] R739.41[医药卫生—诊断学]