通心络胶囊对冠状动脉搭桥患者血管内皮功能及不良心血管事件的影响  

Effect of Tongxinluo Capsule on Vascular Endothelial Function and Adverse Vascular Events in Patients with Coronary Artery Bypass Grafting

作　　者：胡光柱 罗丽娟 HU Guang-zhu;LUO Li-juan(Department of Cardiac surgery,Nanshi Hospital,Nanyang 473000,Henan Province,China;Department of Science and Education,Nanshi Hospital,Nanyang 473000,Henan Province,China)

机构地区：[1]河南南阳南石医院心脏外科,河南南阳473000 [2]河南南阳南石医院科教科,河南南阳473000

出　　处：《罕少疾病杂志》2024年第1期52-54,共3页Journal of Rare and Uncommon Diseases

基　　金：2022年度河南省教育科学规划项目(2022YB0638)。

摘　　要：目的分析通心络胶囊对冠状动脉搭桥患者血管内皮功能及不良心血管事件的影响。方法选取2020年1月~2022年1月收治的择期行冠状动脉搭桥术的冠心病患者100例,筛选后分为两组,各50例。对照组接受阿司匹林、氯吡格雷及他汀类等药物治疗,观察组加用通心络胶囊,均治疗并随访3个月。比较临床指标。结果观察组、对照组移植血管数、术后引流量、手术时间比较,均无明显差异,P>0.05;经比较两组治疗1个月后、治疗3个月后的血清ET-1水平、血浆FIB、MPV水平较治疗前逐渐降低,观察组均低于对照组,治疗1个月后、治疗3个月后的血清NO水平、LVEF水平较治疗前逐渐升高,观察组均高于对照组,观察组患者随访期间不良心血管事件发生率低于对照组(P<0.05)。结论通心络胶囊可有效改善冠状动脉搭桥患者血管内皮功能,改善其血液凝固状态,促进心功能的恢复,降低不良心血管事件的发生风险,临床应用效果显著。Objective To analyze the effect of Tongxinluo capsule on vascular endothelial function and adverse vascular events in patients with coronary artery bypass grafting.Methods 100 patients with coronary heart disease who underwent elective coronary artery bypass grafting from January 2020 to January 2022 were selected and divided into two groups after screening,with 50 cases in each group.The control group received aspirin,clopidogrel and statins,while the observation group was given Tongxinluo capsule.Both groups were treated and followed up for 3 months.The clinical indexes of the two groups were compared.Results There was no significant difference in the number of transplanted blood vessels,postoperative drainage and operation time between the observation group and the control group(P>0.05).Compared with before treatment,the levels of serum ET-1,plasma FIB and MPV of the observation group and the control group decreased gradually after one month and three months of treatment,and the observation group was lower than the control group..After one month and three months of treatment,the levels of serum NO and LVEF increased gradually compared with before treatment,the observation group was higher than the control group..The incidence of adverse cardiovascular events of the observation group was lower than that of the control group(P<0.05).Conclusion Tongxinluo capsule can effectively improve vascular endothelial function,improve blood coagulation state,promote the recovery of cardiac function and reduce the risk of adverse vascular events in patients with coronary artery bypass grafting,and its clinical application effect is remarkable.

关 键 词：冠状动脉搭桥 通心络胶囊 血管内皮功能 不良心血管事件 

分 类 号：R543.3[医药卫生—心血管疾病]