血浆sLRP-1水平对急性冠状动脉综合征患者预后的预测价值研究  

Study of the Predictive Value of Plasma sLRP-1 Level on the Prognosis of Patients with Acute Coronary Syndrome

作　　者：许皓莉 XU Hao-li(Department of encephalopathy,Ruzhou Hospital of Traditional Chinese Medicine,Ruzhou 467500,Henan Province,China)

机构地区：[1]汝州市中医院脑病一科,河南汝州467500

出　　处：《罕少疾病杂志》2024年第1期57-59,共3页Journal of Rare and Uncommon Diseases

基　　金：2021年河南省医学科技攻关计划(LHGJ2021120)。

摘　　要：目的研究血浆可溶性低密度脂蛋白受体相关蛋白-1(sLRP-1)判断急性冠状动脉综合征患者预后的价值。方法通过回顾性分析法选择我院2020年8月-2022年5月收住的急性冠状动脉综合征患者157例进入试验,统计并整理所有患者的临床资料,对比不同冠脉狭窄程度患者的sLRP-1水平,同时比较不同sLRP-1水平患者的不良心血管事件的发生率,观察是否发生不良心血管事件患者的临床资料,将有差异项目通过Logistic回归方程计算,分析影响患者预后的风险因素。结果轻度组sLRP-1水平低于中度、重度组(P<0.05)。两组在年龄、患病至就诊时间、sLRP-1、射血分数(LVEF)、低密度脂蛋白(LDL-C)、空腹血糖上存在显著差别(P<0.05),经Logistics回归方程计算,发现上述指标均成为影响患者预后的风险因素。sLRP-1>0.8mg/L组不良心血管事件发生率高于<0.40mg/L组、0.40-0.8mg/L组(P<0.05)。结论sLRP-1成为判断患者预后的重要指标,能够准确评估患者冠脉狭窄程度,预测不良心血管事件发生的风险,值得推广。Objective To study the value of plasma soluble low-density lipoprotein receptor-associated protein-1(sLRP-1)in determining the prognosis of patients with acute coronary syndrome.Methods The retrospective analysis selected 157 patients with acute coronary syndrome from August 2020 to May 2022,collected the clinical data of all patients,compared the sLRP-1 levels of patients with different coronary stenosis,compared the incidence of adverse cardiovascular events in patients with different sLRP-1 levels,observed the clinical data of adverse cardiovascular event patients,and analyzed the risk factors affecting the prognosis of patients by the Logistic regression equation.Results The sLRP-1 level was lower than that in the moderate and severe group(P<0.05).There were significant differences in age,time from illness to visit,sLRP-1,ejection fraction(LVEF),low density lipoprotein(LDL-C),and fasting blood glucose(P<0.05).Based on the Logistics regression equation,the above indicators were found to be risk factors affecting the prognosis of patients.The incidence of adverse cardiovascular events in sLRP-1>0.8mg/L was<0.40 mg/L and 0.40-0.8mg/L(P<0.05).Conclusion sLRP-1 is an important indicator to judge the prognosis of patients,which can accurately assess the degree of coronary stenosis and predict the risk of adverse cardiovascular events,which is worth popularizing.

关 键 词：急性冠状动脉综合征 可溶性低密度脂蛋白受体相关蛋白-1 预测价值 预后 

分 类 号：R541.4[医药卫生—心血管疾病]