Serum procalcitonin levels are associated with rhabdomyolysis following exertional heatstroke: an over 10-year intensive care survey  

作　　者：Li Zhong Feifei Shuai Conglin Wang Lipeng Han Zhifeng Liu Ming Wu 

机构地区：[1]Department of Traditional Chinese Medicine,the First Affi liated Hospital,Guizhou University of Chinese Medicine,Guiyang 550001,China [2]Department of Medical Critical Care Medicine,General Hospital of Southern Theatre Command of People’s Liberation Army,Guangzhou 510010,China [3]Department of Infection and Critical Care Medicine,Shenzhen Second People’s Hospital&First Affi liated Hospital of Shenzhen University,Health Science Center,Shenzhen 518035,China [4]Department of Nosocomial Infection Prevention and Control,Shenzhen Second People’s Hospital,Shenzhen 518035,China [5]Key Laboratory of Hot Zone Trauma Care and Tissue Repair of People's Liberation Army,General Hospital of Southern Theatre Command of People's Liberation Army,Guangzhou 510010,China

出　　处：《World Journal of Emergency Medicine》2024年第1期23-27,共5页世界急诊医学杂志（英文）

基　　金：funded by the National Natural Science Foundation of China(82072143,81873943,82360903);Sanming Project of Medicine in Shenzhen(SZSM20162011);Shenzhen Science and Technology Innovation Commission(JCYJ20190806163603504);Shenzhen Second People’s Hospital Clinical Research Fund of Guangdong Province High-level Hospital Construction Project(20203357014,2023xgyj3357001,2023yjlcyj022);Guizhou Science and Technology Planning Project(Guizhou Science and Technology Cooperation Support[2021]General 413);and PhD Start-up Fund(GYZYYFY-BS-2023[09]).

摘　　要：BACKGROUND:Heatstroke has become a common emergency event in hospitals.Procalcitonin(PCT)is used as a biomarker of infection in the emergency department(ED),but its role in rhabdomyolysis(RM)following exertional heatstroke(EHS)remains unclear.METHODS:A retrospective cohort study enrolled patients with EHS from the intensive care unit(ICU).We collected RM biomarkers,inflammation markers,critical disease scores at admission,24 h,48 h,and discharge,and 90-day mortality.Correlation analysis,linear regression and curve fi tting were used to identify the relationship between PCT and RM.RESULTS:A total of 162 patients were recruited and divided into RM(n=56)and non-RM(n=106)groups.PCT was positively correlated with myoglobin(Mb),acute hepatic injury,disseminated intravascular coagulation(DIC),Sequential Organ Failure Assessment(SOFA)score,and Acute Physiology and Chronic Health Evaluation II(APACHE II)score,with correlation coefficients of 0.214,0.237,0.285,0.454,and 0.368,respectively(all P<0.05).Interestingly,the results of curve fi tting revealed a nonlinear relationship between PCT and RM,and a two-piecewise linear regression model showed that PCT was related to RM with an odds ratio of 1.3 and a cut-off of<4.6 ng/mL.Survival analysis revealed that RM was associated with higher mortality compared to non-RM cases(P=0.0093).CONCLUSION:High serum PCT concentrations are associated with RM after EHS in critically ill patients.Elevated PCT concentrations should be interpreted cautiously in patients with EHS in the ED.

关 键 词：PROCALCITONIN MYOGLOBIN RHABDOMYOLYSIS Exertional heatstroke 

分 类 号：R594.12[医药卫生—内科学] R685.5[医药卫生—临床医学]