银杏蜜环对ACS患者血清基质金属蛋白酶及其抑制物水平的影响  

Effect of ginkgo biloba honey ring on serum matrix metalloproteinase and its inhibitor levels in patients with ACS

作　　者：丁海强 胡林[1] 杨柳[1] 胡耀[1] 王洪[1] DING Haiqiang;HU Lin;YANG Liu;HU Yao;WANG Hong(Department of Cardiovascular Medicine,Jiangxi Provincial People's Hospital(The First Affiliated Hospital of Nanchang Medical College),Nanchang 330006,China)

机构地区：[1]江西省人民医院南昌医学院第一附属医院心血管内科,南昌330006

出　　处：《江西医药》2023年第10期1114-1118,共5页Jiangxi Medical Journal

基　　金：江西省中医药管理局科技计划课题,编号2020A0214。

摘　　要：目的 探讨银杏蜜环对急性冠脉综合征(ACS)患者血清基质金属蛋白酶及其抑制物水平的影响,为临床预防及治疗急性冠脉综合征提供新的方向。方法 收集66例急性冠脉综合征患者,随机分成两组,每组各33例,两组患者均接受经皮冠状动脉介入治疗(PCI),以银杏蜜环口服液治疗组为实验组,未服用上述药物组为对照组,其余治疗均一致,分析两组患者治疗前后基质金属蛋白酶-9(MMP-9)、组织型基质金属蛋白酶抑制物-2(TIMP-2)及超敏C反应蛋白(hs-CRP)变化情况,探讨银杏蜜环对上诉指标的影响。结果 两组患者行PCI治疗后MMP-9、hs-CRP指标水平较手术前均明显下降,TIMP-2较术前明显升高,实验组使用银杏蜜环口服液后MMP-9、TIMI-2指标较对照组变化更为明显,以上实验结果差异有统计学意义(P<0.05)。结论 银杏蜜环口服液可以降低MMP-9水平和升高TIMP-2水平,提示银杏蜜环口服液在ACS的预防和治疗中具有一定作用。Objective To investigate the effect of ginkgo biloba on serum matrix metalloproteinase and its inhibitor levels in patients with acute coronary syndrome(ACS),and to provide a new direction for clinical prevention and treatment of ACS.Methods Sixty-six patients with acute coronary syndrome were collected and randomly divided into two groups of 33 patients each,and both groups were treated with percutaneous coronary intervention(PCI).Matrix metalloproteinase-9(MMP-9),tissue-type metalloproteinase-inhibitor-2(TIMP-2)and hypersensitive C-reactive protein(hs-CRP)changes were analyzed before and after treatment in both groups to explore the effect of Ginkgo biloba on the appeal index.Results The levels of MMP-9 and hs-CRP indexes in both groups decreased significantly after PCI treatment compared with those before surgery,and TIMP-2 increased significantly compared with those before surgery,and the changes of MMP-9 and TIMI-2 indexes in the experimental group were more obvious than those in the control group after using Ginkgo biloba oral solution,and the above experimental results were statistically different(P<0.05).Conclusion Ginkgo biloba oral liquid can reduce MMP-9 level and increase TIMI-2 level,suggesting that Ginkgo biloba oral liquid has a certain role in the prevention and treatment of ACS.

关 键 词：银杏蜜环口服液 急性冠脉综合征 基质金属蛋白酶-9 组织型基质金属蛋白酶抑制物-2 

分 类 号：R541.4[医药卫生—心血管疾病]