小檗碱抗白血病的药理作用及其机制研究进展  

Research Progress in Pharmacological Effects and Mechanisms of Berberine against Leukemia

作　　者：张明发[1] 沈雅琴[1] ZHANG Ming-fa;SHEN Ya-qin(Shanghai Meiyou Pharmaceutical Co.,Ltd.,Shanghai 201204,China)

机构地区：[1]上海美优制药有限公司,上海201204

出　　处：《抗感染药学》2023年第9期899-903,932,共6页Anti-infection Pharmacy

摘　　要：小檗碱具有抗炎、抗菌、抗病毒、抗肿瘤、抗高血压、降血糖等广泛的药理作用。此前,小檗碱的抗肿瘤研究主要集中在抗肝癌、抗泌尿系统肿瘤、抗妇科肿瘤等方面,鲜少有人整理小檗碱的抗白血病作用及其药理机制。本文主要以小檗碱对K562细胞、HL-60细胞、Jurkat细胞、Molt-4细胞、U937细胞、THP-1细胞的药理作用及其机制为切入点,综述和分析了小檗碱的抗白血病作用及其机制。Berberine has a wide range of pharmacological effects such as anti-inflammatory,antibacterial,antiviral,antitumor,antihypertensive,and hypoglycemic effects.Previous studies on berberine's anti-tumor effects mainly focused on anti-hepatoma,anti-tumors of urinary system,and anti-gynecological tumors,etc.The anti-leukemia effects and pharmacological mechanisms of berberine are rarely studied.In this article,by focusing on the pharmacological effects and mechanisms of berberine on K562 cells,HL-60 cells,Jurkat cells,Molt-4 cells,U937 cells and THP-1 cells,the anti-leukemia effects and mechanisms of berberine are reviewed and analyzed.

关 键 词：小檗碱 抗白血病作用 药理机制 K562细胞 HL-60细胞 JURKAT细胞 MOLT-4细胞 U937细胞 THP-1细胞 

分 类 号：R961[医药卫生—药理学] R773.7[医药卫生—药学]