某院117例左氧氟沙星所致药物不良反应的流行病学分析  

EpidemiologicalAnalysis of 117 Patients with ADRs Caused by Levofloxacin in a Hospital

作　　者：归莱[1,2] 张桂芬 王建[1,2] GUI Lai;ZHANG Gui-fen;WANG Jian(Changshu No.1 People's Hospital,Changshu Jiangsu 215500,China;Affiliated Changshu Hospital of Soochow University,Changshu Jiangsu 215500,China)

机构地区：[1]常熟市第一人民医院,江苏常熟215500 [2]苏州大学附属常熟医院,江苏常熟215500

出　　处：《抗感染药学》2023年第9期908-913,950,共7页Anti-infection Pharmacy

摘　　要：目的:分析医院左氧氟沙星所致药物不良反应(adverse drug reactions,ADRs)的流行病学特点,为临床左氧氟沙星的用药安全提供参考。方法:选取2018年1月—2022年12月常熟市第一人民医院上报的117例左氧氟沙星所致ADRs报告作为研究资料,采集其中患者的年龄、性别、所患疾病,左氧氟沙星的品规、用法用量、给药途径,以及ADRs的累及器官、临床表现、最终转归等信息,分析左氧氟沙星所致ADRs的流行病学特点。结果:117例ADRs报告中,女性多于男性(78例vs 39例),患者所患疾病以下呼吸道感染(33例,占28.21%)、消化系统感染(23例,占19.66%)、女性盆腔及其附件感染(22例,占18.80%)和尿路感染(17例,占14.53%)为主;117例ADRs报告中,所涉左氧氟沙星共涉及7个品规(4个注射液,3个片剂),注射液共涉患者110例(占94.02%),片剂共涉患者7例(占5.98%),左氧氟沙星的给药方案主要为“0.5 g,q24h,静脉滴注”(74例,占63.25%)和“0.2 g,q12h,静脉滴注”(27例,占23.08%);左氧氟沙星所致ADRs主要累及患者的皮肤及其附属器官(66例,占56.41%)和血管系统(18例,占15.38%),有8例临床表现较为严重,具体表现为过敏性休克(6例);但经对症治疗后,所有患者均好转(38例,占32.48%)或治愈(79例,占67.52%)。结论:左氧氟沙星所致ADRs在女性中更为多见,且多发生在静脉滴注用药时,此外其临床表现多数并不严重,但临床仍应重视患者的用药监护,以确保患者的用药安全。Objective:To analyze the epidemiological characteristics of adverse drug reactions(ADRs)caused by levofloxacin in a hospital and provide a reference for clinical medication safety of levofloxacin.Methods:The ADR reports of 117 patients caused by levofloxacin reported by Changshu No.1 People's Hospital from January 2018 to December 2022 were selected as the research data,and the information of the patients such as age,sex,disease,specifications,usage and dosage and route of administration of levofloxacin,as well as organs involved,clinical manifestations and final outcomes of ADRs was collected to analyze the epidemiological characteristics of ADRs caused by levofloxacin.Results:In the ADR reports of 117 patients,there were more females than males(78 vs 39);the patients mainly suffered from the lower respiratory tract infections(33 cases,28.21%),digestive system infections(23 cases,19.66%),female pelvic infections and its adnexal infections(22 cases,18.80%)and urinary tract infections(17 cases,14.53%).According to the ADR reports of 117 patients,7 specifications(4 injections,3 tablets)of levofloxacin were involved;the injections were involved in 110 patients(94.02%),and tablets were involved in 7 patients(5.98%).The dosage regimens of levofloxacin were mainly"0.5 g,q24h,intravenous drip"(74 cases,63.25%)and"0.2 g,q12h,intravenous drip"(27 cases,23.08%).The ADRs caused by levofloxacin mainly involved the patients'skin and accessory organs(66 cases,56.41%)as well as vascular systems(18 cases,15.38%);8 patients had serious clinical manifestations,specifically anaphylactic shock(6 cases).After symptomatic treatment,all patients became improved(38 cases,32.48%)or were cured(79 cases,67.52%).Conclusion:ADRs caused by levofloxacin are more common in women and mostly occur during intravenous drips.In addition,most of the clinical manifestations are not serious,but clinically attention should be paid to the medication monitoring to ensure medication safety for patients.

关 键 词：左氧氟沙星 药物不良反应 流行病学特点 

分 类 号：R978.1[医药卫生—药品] R961[医药卫生—药学]