阿扎胞苷联合小剂量阿糖胞苷对治疗老年急性髓系白血病感染指标的影响  

Effect of Azacytidine Combined with Low-dose Cytarabine on Infection Indexes of Acute Myeloid Leukemia in Elderly Patients

作　　者：刘霞 饶建华 朱丽娟 莫明翠 唐国玲 LIU Xia;RAO Jianhua;ZHU Lijuan;MO Mingcui;TANG Guoling(Department of Pharmacy,Lincang People's Hospital,Lincang,Yunnan Province,677000 China)

机构地区：[1]云南省临沧市人民医院药学科,云南临沧677000

出　　处：《中外医疗》2023年第32期31-34,共4页China & Foreign Medical Treatment

基　　金：临沧市人民医院科技计划项目(2022-15)。

摘　　要：目的 探究阿扎胞苷联合小剂量阿糖胞苷对治疗老年急性髓系白血病炎性因子的影响。方法 采用横断面法,方便选取2019年1月—2023年3月云南省临沧市人民医院接收的急性髓系白血病81例患者为研究对象。利用统计学软件生成随机序列后分为对照组(41例)和观察组(40例)。其中,对照组给予阿糖胞苷,观察组在阿糖胞苷基础上给予阿扎胞苷。治疗完成后,对比两组感染指标及血液学指标。结果 观察组巨噬细胞炎症蛋白-1α(macrophage inflammatory protein-1α,MIP-1α)水平[(151.31±25.69)ng/L]、降钙素原(procalcitonin,PCT)水平[(0.60±0.12)μg/L]、C反应蛋白(C-reactive protein,CRP)水平[(36.57±6.62)mg/L]均低于对照组,差异有统计学意义(t=2.380、2.977、2.822,P<0.05);观察组血红蛋白水平低于对照组,且白细胞计数、血小板计数均高于对照组,差异有统计学意义(t=2.502、2.260、2.000,P<0.05)。结论 对于治疗急性髓系白血病,使用阿扎胞苷联合阿糖胞苷能够明显提高疗效,有利于改善患者的血液学指标,同时降低体内的感染指标水平。Objective To explore the effect of azacytidine combined with low-dose cytarabine on inflammatory factors in the treatment of elderly acute myeloid leukemia.Methods Using cross-sectional method,all 81 patients with acute myeloid leukemia admitted to Lincang People's Hospital in Yunnan Province from January 2019 to March 2023 were conveniently selected as the study objects.Statistical software was used to generate random sequences and they were divided into control group(41 cases) and observation group(40 cases).Among them,the control group was given cytarabine,and the observation group was given azacitidine on the basis of cytarabine.After the completion of treatment,the infection indexes and hematological indexes of the two groups were compared.Results The levels of macrophage inflammatory protein-1α(MIP-1α) [(151.31±25.69) ng/L],procalcitonin(PCT) [(0.60±0.12) μg/L] and C-reactive protein(CRP) [(36.57±6.62) mg/L] in observation group were lower than those in control group,and the differences were statistically significant(t=2.380,2.977,2.822,P<0.05).The hemoglobin level of observation group was lower than that of control group,and the white blood cell count and platelet count were higher than that of control group,and the differences were statistically significant(t=2.502,2.260,2.000,P<0.05).Conclusion For the treatment of acute myeloid leukemia,the use of azacytidine combined with cytarabine can significantly improve the curative effect,which is conducive to improving the hematological indicators of patients and reducing the level of infection indicators in the body,

关 键 词：阿扎胞苷 小剂量阿糖胞苷 老年 急性髓系白血病 感染指标 血液学指标 

分 类 号：R4[医药卫生—临床医学]