铁死亡与自身免疫性疾病的研究进展  

Research Progress of Ferroptosis and Autoimmune Diseases

作　　者：杨慧敏 李志军[1,3] 李柏青[1,3] YANG Huimin;LI Zhijun;LI Baiqing(Key Laboratory of Infection and Immunity of Anhui Higher Education Institutes,Bengbu Medical College,Bengbu 233030,China;Department of Rheumatology and Immunology,the Second Affiliated Hospital of Bengbu Medical College,Bengbu 233000,China;Department of Rheumatology and Immunology,the First Affiliated Hospital of Bengbu Medical College,Bengbu 233000,China)

机构地区：[1]蚌埠医学院感染与免疫安徽普通高校重点实验室,安徽蚌埠233030 [2]蚌埠医学院第二附属医院风湿免疫科,安徽蚌埠233000 [3]蚌埠医学院第一附属医院风湿免疫科,安徽蚌埠233000

出　　处：《医学综述》2023年第24期5585-5590,5600,共7页Medical Recapitulate

基　　金：蚌埠医学院厅级重点实验室开放课题面上项目(AHIAI2022R04)。

摘　　要：自身免疫性疾病是一组病因不明的复杂疾病,均存在自身组织抗原特异性T细胞或B细胞的异常激活和相应组织器官的炎症反应,且与不能有效清除自身衰老损伤细胞有关。铁死亡是一种新型的非凋亡性细胞死亡形式,主要生化特征包括铁过载、氧化应激、脂质过氧化和抗氧化通路受损。近年认为铁死亡与自身免疫性疾病(如系统性红斑狼疮、类风湿关节炎)的发生发展相关,这可能为自身免疫性疾病的发病机制研究和新药研发提供新方向。Autoimmune diseases are a group of complex diseases with unknown etiology,all of which involve abnormal activation of antigen-specific T or B cells in their own tissues and inflammatory reactions in corresponding tissues and organs,and are related to the failure to effectively eliminate self aging damaged cells.Ferroptosis is a new form of non-apoptotic cell death,with main biochemical characteristics including iron overload,oxidative stress,lipid peroxidation,and impaired antioxidant pathways.In recent years,research has found that ferroptosis is related to the occurrence and development of autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis,which may provide new directions for the pathogenesis research and new drug development of autoimmune diseases.

关 键 词：自身免疫性疾病 铁死亡 免疫细胞 

分 类 号：R541.4[医药卫生—心血管疾病]