组织工程材料在鼓膜修补中的应用进展  

Progress in Application of Tissue Engineering Materials in Tympanic Membrane Repair

作　　者：李硕[1] 胡浩磊 岳玮 徐弢[3] 殷钢 李谊 LI Shuo;HU Haolei;YUE Wei;XU Tao;YIN Gang;LI Yi(Xinxiang Medical University,Xinxiang 453003,China;Department of Otolaryngology and Maxillofacial Surgery,the 988th Hospital of the Joint Support Force of the Chinese PLA,Zhengzhou 450000,China;Biological Manufacturing Center,Department of Mechanical Engineering,Tsinghua University,Beijing 100084,China)

机构地区：[1]新乡医学院,河南新乡453003 [2]联勤保障部队第九八八医院耳鼻咽喉颌面外科,郑州450000 [3]清华大学机械工程系生物制造中心,北京100084

出　　处：《医学综述》2023年第24期5680-5684,5690,共6页Medical Recapitulate

基　　金：河南省医学科技攻关计划项目(LHGJ20220916)。

摘　　要：鼓膜修补材料是耳科医师治疗鼓膜穿孔的重要材料。随着组织工程技术的发展,人工鼓膜修补材料受到越来越多研究者的关注。这些材料主要集中在3个方面,包括支架、生长因子和干细胞。由于支架能够在鼓膜穿孔处为细胞的迁移、附着及增殖提供支撑结构,出现了许多新颖的支架材料,如贴片、静电纺丝支架。相反,生长因子或干细胞近年仅作为辅助材料联合支架一同用于鼓膜修补。这些材料的出现使得组织工程鼓膜修补材料在治疗鼓膜穿孔上具有巨大潜力,未来可能代替自体组织用于鼓膜穿孔的修补。Tympanic membrane repair material is an important material for otologists to treat tympanic membrane perforation.With the development of tissue engineering technology,more and more researchers are paying attention to artificial tympanicmembrane repair materials,which mainly focus on three aspects,including scaffolds,growth factors and stem cells.Because scaffolds can provide support structures for cell migration,adhesion and proliferation at the perforation of tympanic membrane,many novel scaffolds,such as films,electrospinning scaffolds,have emerged.In contrast,growth factors or stem cells have only been used in recent years as auxiliary materials in conjunction with scaffolds for tympanic membrane repair.The emergence of these materials offers tissue engineering tympanic membrane repair materials great potential in the treatment of tympanic membrane perforation,and can replace autologous tissue in the future.

关 键 词：鼓膜穿孔 静电纺丝 组织工程 修补材料 

分 类 号：R764.9[医药卫生—耳鼻咽喉科]